Label-Free Technologies for Drug Discovery

Label-Free Technologies for Drug Discovery

Editor(s): Matthew Cooper, Lorenz M. Mayr

Published Online: 24 FEB 2011 10:15PM EST

Print ISBN: 9780470746837

Online ISBN: 9780470979129

DOI: 10.1002/9780470979129

About this Book

Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories.

Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.

Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.

Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

Table of contents

    1. You have free access to this content
    2. Chapter 4

      The CellKey® System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications (pages 57–70)

      Ryan P. McGuinness, Debra L. Gallant, Yen-Wen Chen, Trisha A. Tutana, Donna L. Wilson, John M. Proctor and H. Roger Tang

    3. Chapter 9

      Expanding the Scope of HTMS Methods (pages 125–139)

      Tom G. Holt, Jun Wang, Xun Chen, Bernard K. Choi, Neil S. Geoghagen, Kristian K. Jensen, Maxine Jonas, Qi Luo, William A. LaMarr, Lorraine Malkowitz, Can C. Ozbal, Yusheng Xiong, Claude Dufresne and Ming-Juan Luo

    4. Chapter 15

      Novartis Evaluation of the ForteBio Octet RED: A Versatile Instrument for Direct Binding Experiments (pages 223–240)

      Eric Martin, John Wang, Isabel Zaror, Jiamin Yu, Kelly Yan, Mike Doyle, Paul Feucht, Kevin Shoemaker, Bob Warne, Mike Chin, Blisseth Sy, Lukas Leder, Marco Meyerhofer, Charles Wartchow and Danfeng Yao

    5. You have free access to this content