Viral Therapy of Cancer

Viral Therapy of Cancer

Editor(s): Kevin J. Harrington, Richard G. Vile, Hardev S. Pandha

Published Online: 4 JUN 2008

Print ISBN: 9780470019221

Online ISBN: 9780470985793

DOI: 10.1002/9780470985793

About this Book

In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. 

This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient's bedside, they give an up-to-date and realistic evaluation of a therapy's potential utility for the cancer patient.

  • Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer
  • Describes the use of viruses as oncolytic agents, killing cells directly
  • Editors are experts in the field, with experience of both laboratory and clinical research

Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

Table of contents

    1. You have free access to this content
    2. Chapter 1

      Adenoviruses (pages 1–17)

      Kate Relph, Kevin J. Harrington, Alan Melcher and Hardev S. Pandha

    3. Chapter 2

      Application of HSV-1 Vectors to the Treatment of Cancer (pages 19–53)

      Paola Grandi, Kiflai Bein, Costas G. Hadjipanayis, Darren Wolfe, Xandra O. Breakefield and Joseph C. Glorioso

    4. Chapter 4

      Retroviruses (pages 69–81)

      Simon Chowdhury and Yasuhiro Ikeda

    5. Chapter 9

      Oncolytic Vaccinia (pages 151–169)

      M. Firdos Ziauddin and David L. Bartlett

    6. Chapter 16

      Gene-Directed Enzyme Prodrug Therapy (pages 255–276)

      Silke Schepelmann, Douglas Hedley, Lesley M. Ogilvie and Caroline J. Springer

    7. Chapter 19

      Radiosensitization in Viral Gene Therapy (pages 313–326)

      Jula Veerapong, Kai A. Bickenbach and Ralph R. Weichselbaum

    8. Chapter 20

      Radioisotope Delivery (pages 327–340)

      Inge D. L. Peerlinck and Georges Vassaux

    9. Chapter 22

      Chemoprotective Gene Delivery (pages 377–391)

      Michael Milsom, Axel Schambach, David Williams and Christopher Baum

    10. You have free access to this content