Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms

Cardiovascular Development and Congenital Malformations: Molecular & Genetic Mechanisms

Editor(s): Michael Artman, D. Woodrow Benson, Deepak Srivastava, Makoto Nakazawa

Published Online: 16 NOV 2007

Print ISBN: 9781405131285

Online ISBN: 9780470988664

DOI: 10.1002/9780470988664

About this Book

Congenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance.


This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding and unique treatise on this pressing topic.

Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development. Sections are accompanied by editorial overviews which integrate new findings and place the information into a broader context.

Table of contents

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  1. Part 1: Establishing Left-Right Patterning and Cardiac Looping

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    2. Chapter 4

      Pleiotropic Effects of Pitx2 Isoform C on Morphogenesis in the Mammalian Heart (pages 14–16)

      Nigel A. Brown, Louisa M. Jones, Oliver A. T. Lyons, Chengyu Liu, Wei Liu, Jennifer Palie, Mei Fang Lu and James F. Martin

  2. Part 2: Mechanisms of Cardiogenesis and Myocardial Development

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    2. Chapter 7

      TBX5 Regulates Cardiac Cell Behavior During Cardiogenesis (pages 27–30)

      Cathy J. Hatcher, Min-Su Kim, David Pennisi, Yan Song, Nata Diman, Marsha M. Goldstein, Takashi Mikawa and Craig T. Basson

    3. Chapter 9

      Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube (pages 37–40)

      Maurice J. B. van den Hoff, Boudewijn P. T. Kruithof, Andy Wessels, Roger R. Markwald and Antoon F. M. Moorman

    4. Chapter 11

      Teratogenic Effects of Bisdiamine on the Developing Myocardium (pages 44–46)

      Nobuhiko Okamoto, Masao Nakagawa, Hidetoshi Fujino, Setsuko Nishijima, Takashi Hanato, Tsutomu Narita and Kyoko Yoshida-Imanaka

  3. Part 3: Formation of Endocardial Cushions and Valves

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    2. Chapter 15

      Valvulogenesis: Role of Periostin in Cushion Tissue Differentiation (pages 62–65)

      Roger R. Markwald, Edward L. Krug, Stan Hoffman, Ricardo Moreno-Rodriguez, Laura Villavicencio, Corey H. Mjaatvedt and Simon J. Conway

    3. Chapter 16

      Role of Fibroblast Growth Factors in Early Valve Leaflet Formation (pages 66–68)

      Yukiko Sugi, Naoki Ito, Gyorgyi Szebenyi, John F. Fallon, Takashi Mikawa and Roge R. Markwald

  4. Part 4: Segment and Chamber Specification

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    2. Chapter 20

      Fgf10 and the Embryological Origin of Outflow Tract Myocardium (pages 81–83)

      Robert G. Kelly, Stephane Zaffran, Margaret Buckingham and Nigel A. Brown

  5. Part 5: Formation of Specialized Conduction Tissues

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    2. Chapter 22

      Induction and Patterning of the Impulse Conducting Purkinje Fiber Network (pages 91–94)

      Takashi Mikawa, Robert G. Gourdie, Clifton P. Poma, Maxim Shulimovich, Christopher Hall, Kenneth W. Hewett, Chip Justus, Maria Reckova, David Sedmera, Kimimasa Tobita, Romulo Hurtado, David J. Pennisi, Nobuyuki Kanzawa and Kimiko Takebayashi-Suzuki

  6. Part 6: Coronary Artery Development

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    2. Chapter 27

      Development of Proximal Coronary Artery in Quail Embryonic Heart (pages 109–111)

      Katsumi Ando, Yuji Nakajima, Toshiyuki Yamagishi, Sadamu Yamamoto and Hiroaki Nakamura

    3. Chapter 28

      Possible Roles of the Extracellular Matrix in Coronary Vasculogenesis of Mouse (pages 112–115)

      Kyoko Imanaka-Yoshida, Mari Hara, Miyuki Namikata, Keiichi Miyamoto, Takashi Hanato, Noriko Watanabe, Masao Nakagawa and Toshimichi Yoshida

    4. Chapter 29

      Abnormal Coronary Development in Bisdiamine Treated Embryo (pages 116–118)

      Takashi Hanato, Masao Nakagawa, Nobuhiko Okamoto, Setsuko Nishijima, Hidetoshi Fujino and Yoshihiro Takeuchi

  7. Part 7: Models of Congenital Cardiovascular Malformations

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    2. Chapter 34

      New Insights into the Role of Tbx1 in the Digeorge Mouse Model (pages 135–136)

      Lazaros Kochilas, Jun Liao, Sandra Merscher-Gomez, Raju Kucherlapati, Bernice Morrow and Jonathan A. Epstein

  8. Part 8: Role of Neural Crest Cells in Cardiovascular Development

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    2. Chapter 37

      TGF-β2 does not affect Neural Crest Cell Migration but is a Key Player in Vascular Remodeling During Embryogenesis (pages 148–149)

      Daniel G. M. Molin, Marco C. Deruiter, Thomas Doetschman, Henry M. Sucov, Robert E. Poelmann and Adriana C. Gittenberger-de Groot

  9. Part 9: Formation of Outflow Tracts

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  10. Part 10: Imaging Techniques

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    2. Chapter 41

      Imaging of Heart Development in Embryos with Magnetic Resonance Microscopy (pages 163–165)

      Bianca Hogers, Dieter Gross, Volker Lehmann, Huub J. M. de Groot, Kees Erkelens, Adriana C. Gittenberger-de Groot and Robert E. Poelmann

  11. Part 11: Cardiovascular Physiology During Development

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    2. Chapter 42

      Shear Stress in the Developing Cardiovascular System (pages 169–173)

      Robert E. Poelmann, Adriana C. Gittenberger-de Groot, Bianca C. W. Groenendijk, Beerend P. Hierck, Bianca Hogers, Frans T. M. Nieuwstadt, Mathieu J. B. M. Pourquie, Paul Steendijk, Sandra Stekelenburg-de Vos, Nicolette T. C. Ursem and Jury W. Wladimiroff

  12. Part 12: Patent Ductus Arteriosus

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    2. Chapter 51

      A Comprehensive Model for O2 Constriction in the Human Ductus Arteriosus (pages 207–210)

      Evangelos D. Michelakis, Bernard Thébaud, Xi-Chen Wu, Kyoko Hashimoto, Rohit Moudgil, Gwyneth Harry, Ivan M. Rebeyka and Stephen L. Archer

  13. Part 13: Human Clinical Genetics and Epidemiology

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    2. Chapter 57

      Familial Recurrence Risks of Congenital Heart Defects (pages 232–234)

      M. Cristina Digilio, Bruno Marino, Rossella Capolino, Anna Sarkozy and Bruno Dallapiccola

    3. Chapter 60

      Cardiovascular Anomalies in Patients with Deletion 22q11.2: A Multicenter Study in Korea (pages 242–243)

      In Sook Park, Young Hwue Kim, Jae Kon Ko, Jung Yun Choi, Soo Jin Kim, Hong Ryang Kil, June Huh, Heung Jae Lee, Jae Sook Ma, Sang Bum Lee, Eul Ju Seo and Han Wook Yoo

    4. Chapter 61

      Atrioventricular Canal Defect: Anatomical and Genetic Characteristics (pages 244–247)

      Bruno Marino, Maria Cristina Digilio, Federica Mileto, Emanuela Conti and Bruno Dallapiccola

    5. Chapter 66

      Missense Mutations in the PTPN11 as a Cause of Cardiac Defects Associated with Noonan Syndrome (pages 273–276)

      Mitsuhiro Kamisago, Kayoko Hirayama-Yamada, Taichi Kato, Shinichiro Imamura, Kunitaka Joo, Masahiko Ando, Atsuyoshi Takao, Kazuo Momma, Makoto Nakazawa and Rumiko Matsuoka

    6. Chapter 67

      Novel Gene Mutations in Patients with Left Ventricular Noncompaction and Evidence for Genetic Heterogeneity (pages 277–278)

      Fukiko Ichida, Chen Rui, Tohru Tsuji, Noriyuki Haneda, Karla R. Bowles, Shinichi Tsubata, Keiichiro Uese, Keiichi Hirono, Sayaka Watanabe, Yuji Hamamichi, Ikuo Hashimoto, Toshio Miyawaki, Neil E. Bowles and Jeffrey A. Towbin

    7. Chapter 68

      Mitochondrial 16189 DNA Variant and left Ventricular Hypertrophy in Diabetes Mellitus (pages 279–281)

      Yukihiko Momiyama, Michiko Furutani, Yoshihiko Suzuki, Shinichiro Imamura, Kazuhiro Hosokawa, Yoshihito Atsumi, Kempei Matsuoka, Mitsuru Kimura, Hiroshi Kasanuki, Fumitaka Ohsuzu and Rumiko Matsuoka

    8. Chapter 69

      Mutation Analysis of BMPR2 and other Genes in Japanese Patients with Pediatric Primary Pulmonary Hypertension (pages 282–284)

      Maya Fujiwara, Tsutomu Saji, Tomotaka Nakayama, Kaoru Akimoto, Michiko Furutani, Shinichiro Imamura, Atsuyoshi Takao, Makoto Nakazawa and Rumiko Matsuoka

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