Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Editor(s): Darrell R. Boverhof, B. Bhaskar Gollapudi

Published Online: 18 JUL 2011 07:26AM EST

Print ISBN: 9780470449820

Online ISBN: 9781118001042

DOI: 10.1002/9781118001042

About this Book

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Table of contents

    1. You have free access to this content
    2. You have free access to this content
    3. Chapter 2

      Introduction to Human Health Risk Assessment (pages 13–40)

      Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui and Lynne T. Haber

    4. Chapter 4

      Approaches and Practical Considerations for the Analysis of Toxicogenomics Data (pages 65–79)

      Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, Lei Guo and Leming Shi

    5. Chapter 9

      Toxicogenomic Studies in Human Populations (pages 177–206)

      Cliona M. McHale, Luoping Zhang, Alan E. Hubbard and Martyn T. Smith

    6. Chapter 13

      Toxicogenomics and Animal Alternatives (pages 267–291)

      Anne S. Kienhuis, Joost H. M. van Delft and Jos C. S. Kleinjans

    7. Chapter 14

      Toxicogenomics and the Regulatory Framework (pages 293–321)

      Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf and William H. Benson

    8. You have free access to this content