HIV-1 Integrase: Mechanism and Inhibitor Design

HIV-1 Integrase: Mechanism and Inhibitor Design

Editor(s): Nouri Neamati

Published Online: 28 SEP 2011 09:48AM EST

Print ISBN: 9780470184745

Online ISBN: 9781118015377

DOI: 10.1002/9781118015377

Series Editor(s): Binghe Wang

About this Book

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

Table of contents

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    2. You have free access to this content
    3. Chapter 4

      Structural Studies of Retroviral Integrases (pages 35–49)

      Mariusz Jaskolski, Jerry N. Alexandratos, Grzegorz Bujacz and Alexander Wlodawer

    4. Chapter 9

      Cellular Cofactors of HIV Integration (pages 105–129)

      Wannes Thys, Koen Bartholomeeusen, Zeger Debyser and Jan De Rijck

    5. Chapter 12

      Assays for Evaluation of HIV-1 Integrase Enzymatic Activity, DNA Binding, and Cofactor Interaction (pages 151–163)

      Frauke Christ, Katrien Busschots, Jelle Hendrix, Melissa McNeely, Yves Engelborghs and Zeger Debyser

    6. Chapter 16

      Conformationally Constrained Tricyclic HIV Integrase Inhibitors (pages 239–254)

      Maria Fardis, Haolun Jin, Xiaowu Chen, Manuel Tsiang, James Chen, Choung Kim and Matthew Wright

    7. Chapter 19

      Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors (pages 275–286)

      Ira B. Dicker, Michael A. Walker, Zeyu Lin, Brian Terry, Lori Pajor, Ming Zheng, B. Narasimhulu Naidu, Jacques Banville, Nicholas A. Meanwell and Mark Krystal

    8. Chapter 22

      Development of Styrylquinoline Integrase Inhibitors (pages 325–339)

      Jean-François Mouscadet, Eric Deprez, Didier Desmaele and Jean D'Angelo

    9. Chapter 30

      Resistance to Inhibitors of HIV-1 Integrase (pages 477–498)

      Anneleen Hombrouck, Reginald Clayton, Arnout Voet, Myriam Witvrouw and Zeger Debyser

    10. You have free access to this content
    11. You have free access to this content