Development of Vaccines: From Discovery to Clinical Testing

Development of Vaccines: From Discovery to Clinical Testing

Editor(s): Manmohan Singh, Indresh K. Srivastava

Published Online: 6 JUN 2011 08:40AM EST

Print ISBN: 9780470256374

Online ISBN: 9781118023648

DOI: 10.1002/9781118023648

About this Book

Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experiences of toxicology testing and regulatory filing for vaccines is also included.

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part 1: Immunogen Design

  2. Part 2: Vaccine Platforms

    1. Chapter 4

      Virus-Like Particle Vaccines: Advantages and Challenges (pages 95–124)

      Ted M. Ross, Nitin Bhardwaj, Hermancia S. Eugene, Brendan M. Giles, Sean P. McBurney, Shannan L. Rossi, Kirsten Schneider-Ohrum and Xian-Chun Tang

    2. Chapter 5

      Design Platforms of Nanocapsules for Human Therapeutics or Vaccines (pages 125–139)

      Masaaki Kawano, Li Xing, Kit S. Lam, Hiroshi Handa, Tatsuo Miyamura, Susan Barnett, Indresh K. Srivastava and R. Holland Cheng

    3. Chapter 8

      DNA Vaccines for Infectious Diesase (pages 215–242)

      Samuel Stepenson, Manmohan Singh and Indresh K. Srivastava

    4. Chapter 9

      Developing Stable Cell Lines for the Production of Vaccine Antigens (pages 243–259)

      Xiaotian Zhong, Zhijian Lu, Richard Zollner, Jimin Zhang, Emily Braunstein, Narender Kalyan and Maninder Sidhu

  3. Part 3: Characterization of Immunogens

  4. Part 4: Formulation Optimization and Stability Evaluation

    1. Chapter 12

      Structural Characteristics Predict the Stability of HIV (pages 305–325)

      Zohar Biron-Sorek, Yide Sun, Elaine Kan, Jeanne Flandez, Michael Franti, Jeffrey Ulmer, Susan Barnett and Indresh K. Srivastava

    2. Chapter 14

      Lyophilization and Stabilization of Vaccines (pages 385–397)

      James Chesko, Chris Fox, Tim Dutill, Thomas Vedvick and Steve Reed

  5. Part 5: Clinical and Manufacturing Issues

    1. You have free access to this content

SEARCH