Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery

Editor(s): Jens-Uwe Peters

Published Online: 28 FEB 2012 03:28AM EST

Print ISBN: 9780470590904

Online ISBN: 9781118098141

DOI: 10.1002/9781118098141

About this Book

An essential outline of the main facets of polypharmacology in drug discovery research

Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide:

  • Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes

  • Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles

  • Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology

  • Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology

A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.

Table of contents

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    1. You have free access to this content
  1. Part A: Polypharmacology: A Safety Concern in Drug Discovery

    1. Chapter 2

      Screening for Safety-Relevant Off-Target Activities (pages 15–46)

      Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov and Kamal Azzaoui

  2. Part B: Polypharmacology: An Opportunity for Drug Discovery

  3. Part C: Selected Approaches to Polypharmacological Drug Discovery

    1. Chapter 13

      Computational Multitarget Drug Discovery (pages 263–301)

      Jeremy A. Horst, Adrian Laurenzi, Brady Bernard and Ram Samudrala

    2. Chapter 14

      Behavior-Based Screening as an Approach to Polypharmacological Ligands (pages 303–313)

      Dani Brunner, Vadim Alexandrov, Barbara Caldarone, Taleen Hanania, David Lowe, Jeff Schneider and Jayaraman Chandrasekhar

    3. Chapter 15

      Multicomponent Therapeutics (pages 315–321)

      Alexis A. Borisy, Grant R. Zimmermann and Joseph Lehár

  4. Part D: Case Studies

    1. Chapter 16

      Discovery of Sunitinib as a Multitarget Treatment of Cancer (pages 323–342)

      Catherine Delbaldo, Camelia Colichi, Marie-Paule Sablin, Chantal Dreyer, Bertrand Billemont, Sandrine Faivre and Eric Raymond

    1. You have free access to this content