Data Management of Protein Interaction Networks

Data Management of Protein Interaction Networks

Author(s): Mario Cannataro, Pietro Hiram Guzzi

Published Online: 10 FEB 2012 11:20AM EST

Print ISBN: 9780470770405

Online ISBN: 9781118103746

DOI: 10.1002/9781118103746

Series Editor(s): Yi Pan, Albert Y. Zomaya

About this Book

Current PPI databases do not offer sophisticated querying interfaces and especially do not integrate existing information about proteins. Current algorithms for PIN analysis use only topological information, while emerging approaches attempt to exploit the biological knowledge related to proteins and kinds of interaction, e.g. protein function, localization, structure, described in Gene Ontology or PDB.  The book discusses technologies, standards and databases for, respectively, generating, representing and storing PPI data. It also describes main algorithms and tools for the analysis, comparison and knowledge extraction from PINs. Moreover, some case studies and applications of PINs are also discussed.

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