Advances in Enzymology: And Related Areas of Molecular Biology

Copyright © 2011 John Wiley & Sons, Inc.

Advances in Enzymology: And Related Areas of Molecular Biology

Editor(s): Eric J. Toone

Published Online: 13 OCT 2011 07:41AM EST

Print ISBN: 9781118014288

Online ISBN: 9781118105771

DOI: 10.1002/9781118105771

About this Book

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About The Product

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xi)

    2. You have free access to this content
      Color Plates (pages c1–c12)

    3. Structure and Regulation of Type 2 Transglutaminase in Relation to its Physiological Functions and Pathological Roles (pages 1–46)

      Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang and Martin Griffin

    4. Physiopathological Roles of Human Transglutaminase 2 (pages 47–95)

      Vittorio Gentile

    5. Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate (pages 97–160)

      Guylaine Hoffner, Amandine Van Houtteghem, William André and Philippe Djian

    6. Transglutaminase 2: A New Paradigm for NF-κB Involvement in Disease (pages 161–195)

      Soo-Youl Kim

    7. Transglutaminase 2 at the Crossroads between Cell Death and Survival (pages 197–246)

      Mauro Piacentini, Manuela D'Eletto, Laura Falasca, Maria Grazia Farrace and Carlo Rodolfo

    8. Tissue Transglutaminase and its Role in Human Cancer Progression (pages 247–293)

      Bo Li, Richard A. Cerione and Marc Antonyak

    9. Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/− Mouse (pages 295–345)

      Zsuzsa Szondy, Ilma Korponay-Szabó, Róbert Király and László Fésüs

    10. Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases (pages 347–383)

      Zoltán Nemes

    11. Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan (pages 385–414)

      Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua Xue, Oksana Lockridge and Athar H. Chishti

    12. Irreversible Inhibitors of Tissue Transglutaminase (pages 415–447)

      Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane and Christophe Pardin

    13. Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) (pages 449–521)

      María A. Pajares and George D. Markham

    14. You have free access to this content
      Index (pages 523–548)

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