Transmembrane Dynamics of Lipids

Transmembrane Dynamics of Lipids

Editor(s): Philippe F. Devaux, Andreas Herrmann

Published Online: 14 OCT 2011 02:00PM EST

Print ISBN: 9780470388457

Online ISBN: 9781118120118

DOI: 10.1002/9781118120118

Series Editor(s): Vladimir N. Uversky

About this Book


Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.

Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems.

The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.

Table of contents

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  1. Part I: Assessing Transmembrane Movement and Asymmetry of Lipids

  2. Part II: Lipid Asymmetry in Cell Membranes

  3. Part III: Energy-Independent Protein-Mediated Transmembrane Movement of Lipids

  4. Part IV: Energy-Dependent Lipid Transport Across Membranes

    1. Chapter 9

      Coupling Drs2p to Phospholipid Translocation, Membrane Asymmetry, and Vesicle Budding (pages 171–197)

      Xiaoming Zhou, Paramasivam Natarajan, Baby-Periyanayaki Muthusamy, Todd R. Graham and Ke Liu

    2. Chapter 11

      The Flippase Delusion? (pages 225–249)

      Naomi L. Pollock, Petra H. M. Niesten and Richard Callaghan

  5. Part V: Relevance of Lipid Transmembrane Distribution for Membrane Properties and Processes

    1. Chapter 13

      Endocytosis and Lipid Asymmetry (pages 275–287)

      Nina Ohlwein, Andreas Herrmann and Philippe F. Devaux

  6. Part VI: Apoptosis and Diseases: Consequences of Disruption to Lipid Transmembrane Asymmetry

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