Applications of Ion Chromatography for Pharmaceutical and Biological Products

Copyright © 2012 John Wiley & Sons, Inc.

Applications of Ion Chromatography for Pharmaceutical and Biological Products

Editor(s): Lokesh Bhattacharyya, Jeffrey S. Rohrer

Published Online: 28 FEB 2012 03:24AM EST

Print ISBN: 9780470467091

Online ISBN: 9781118147009

DOI: 10.1002/9781118147009

About this Book

Product Information

About The Product

This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xii)

  2. Part I: Principles, Mechanism, and Instrumentation

    1. Chapter 1

      Ion Chromatography—Principles and Applications (pages 1–21)

      Lokesh Bhattacharyya

    2. Chapter 2

      Retention Processes in Ion-Exclusion Chromatography: A New Perspective (pages 23–47)

      Milko Novič and Paul R. Haddad

    3. Chapter 3

      Pulsed Electrochemical Detection in Ion Chromatography (pages 49–90)

      William R. Lacourse

    4. Chapter 4

      Suppressor Design and Detection for Ion Chromatography (pages 91–105)

      Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher Pohl

    5. Chapter 5

      Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically Relevant Organic Ions (pages 107–133)

      Philip Zakaria, Greg Dicinoski, Melissa Hanna-Brown and Paul R. Haddad

  3. Part II: Pharmaceutical Applications

    1. Chapter 6

      Ion Chromatography in Pharmaceutical Drug Analysis (pages 135–157)

      Lokesh Bhattacharyya

    2. Chapter 7

      Analysis for Impurities by Ion Chromatography (pages 159–174)

      Shreekant V. Karmarkar

    3. Chapter 8

      Ion Chromatography Analysis of Aminoglycoside Antibiotics (pages 175–192)

      Valoran P. Hanko and Jeffrey S. Rohrer

    4. Chapter 9

      Use of Cation-Exchange Ion Chromatography in the Analysis of Pharmaceuticals (pages 193–220)

      Christopher Pohl, Maria Rey and Rosanne Slingsby

    5. Chapter 11

      High Performance Ion Chromatographic Analysis of Cholinergic Compounds: Carbachol and Bethanechol, and Associated Degradation Products (pages 237–245)

      David Trowbridge

    6. Chapter 12

      Ion Chromatographic Analysis of Pharmaceuticals for Authenticity and Adulteration (pages 247–257)

      David S. Jackson

    7. Chapter 13

      Ion Chromatography of Drug Product Counter-Ions and other Ions in Drug Products (pages 259–269)

      Brian M. De Borba and Jeffrey S. Rohrer

    8. Chapter 14

      Sample Preparation Techniques in Ion Chromatography for Pharmaceutical Applications (pages 271–283)

      Jay Gandhi

    9. Chapter 15

      Validation of Ion Chromatographic Methods (pages 285–308)

      Shreekant V. Karmarkar

    10. Chapter 16

      Pharmacopeial Applications of Ion Chromatography (pages 309–320)

      Ravi Ravichandran

    1. Chapter 10

      Comprehensive Approaches for Measurement of Active Pharmaceutical Ingredients, Counter-Ions, and Excipients Using HPLC with Charged Aerosol Detection (pages 221–236)

      Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian Acworth

  5. Part III: Biotechnology Applications

    1. Chapter 17

      Glycan Analysis by High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (pages 321–338)

      Lokesh Bhattacharyya

    2. Chapter 18

      Monosaccharide Analysis of Glycoproteins by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection (pages 339–350)

      Jeffrey S. Rohrer

    3. Chapter 19

      Two-Dimensional Ion Chromatography for Simultaneous Determination of Amino Acids and Carbohydrates (pages 351–364)

      Petr Jandik and Jun Cheng

    4. Chapter 20

      Monitoring Protein N-Glycosylation Consistency Using HPAEC-PAD (pages 365–377)

      Carl Grey

    5. Chapter 21

      Oligosaccharide Analysis by High-Performance Anion-Exchange Chromatography Hyphenated to Integrated Pulsed Amperometric Detection and On-Line Ion-Trap Mass Spectrometry (pages 379–391)

      Cees Bruggink

  6. Part IV: Vaccine Applications

    1. Chapter 22

      Applications of Ion Chromatography in Biological Product Analyses (pages 393–421)

      Alfred V. Del Grosso and Brandon Duong

    2. Chapter 23

      High Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD) Analysis of GBS Glycoconjugate Vaccines: From Fermentation to Final Product (pages 423–434)

      Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'Ascenzi

    3. Chapter 24

      Stability Studies and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435–447)

      Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi

  7. Part V: Appendices

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      Appendix 1: Dissociation Constants (pKa) of Organic Acids (at 20°C) (pages 449–453)

    2. You have free access to this content
      Appendix 2: Dissociation Constants (pKa) of Common Sugars and Alcohols (pages 455–456)

    1. You have free access to this content
      Index (pages 457–463)

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