Mass Spectrometry Handbook

Copyright © 2012 John Wiley & Sons, Inc.

Mass Spectrometry Handbook

Editor(s): Mike S. Lee

Published Online: 21 MAY 2012 01:56AM EST

Print ISBN: 9780470536735

Online ISBN: 9781118180730

DOI: 10.1002/9781118180730

Series Editor(s): Mike S. Lee

About this Book

Product Information

About The Product

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Table of contents

    1. You have free access to this content
      FrontMatter (pages i–xxi)

  2. Section I: Biotechnology/Proteins

    1. Chapter 1

      Targeted Proteomics Using Immunoaffinity Purification (pages 1–21)

      Karen R. Jonscher, Lei Jin, John C. Cambier, Shaikh M. Rahman and Jacob E. Friedman

    2. Chapter 2

      Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifications by Lipid Peroxidation Products (pages 23–40)

      Navin Rauniyar and Laszlo Prokai

    3. Chapter 3

      Imaging Mass Spectrometry (IMS) for Biological Application (pages 41–83)

      Yuki Sugiura, Ikuko Yao and Mitsutoshi Setou

    4. Chapter 4

      Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs (pages 85–105)

      George W. Jackson, Rafal Drabek, Mithil Soni, Roger McNichols, Richard C. Willson and George E. Fox

  3. Section II: Pharmaceutical

    1. Chapter 5

      Preclinical Pharmacokinetics: Industrial Perspective (pages 107–118)

      Ayman El-Kattan and Manthena Varma

    2. Chapter 6

      LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective (pages 119–169)

      Wenying Jian, Wilson Shou, Richard W. Edom, Naidong Weng and Mingshe Zhu

    3. Chapter 7

      Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies (pages 171–189)

      Xiaoying Xu and Wenkui Li

    4. Chapter 8

      Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS (pages 191–207)

      Margrét Thorsteinsdóttir, Baldur Bragi Sigurðsson and Gísli Bragason

    5. Chapter 9

      Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS (pages 209–226)

      Kevin A. Schug

    6. Chapter 10

      Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products (pages 227–241)

      Igor A. Kaltashov, Cedric E. Bobst and Rinat R. Abzalimov

    7. Chapter 11

      TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods (pages 243–258)

      Satoka Aoyagi

    8. Chapter 12

      Accelerator Mass Spectrometry in Pharmaceutical Development (pages 259–269)

      Benjamin J. Stewart, Graham Bench, Bruce A. Buchholz, Kurt W. Haack, Michael A. Malfatti, Ted J. Ognibene and Kenneth W. Turteltaub

  4. Section III: Clinical Analysis

    1. Chapter 13

      Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism (pages 271–295)

      Donald H. Chace

    2. Chapter 14

      Mass Spectrometry for Steroid Analysis (pages 297–337)

      William J. Griffiths, Michael Ogundare, Anna Meljon and Yuqin Wang

  5. Section IV: Forensics

    1. Chapter 15

      Forensic Applications of Isotope Ratio Mass Spectrometry (pages 339–372)

      Sarah J. Benson

    2. Chapter 16

      Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry (pages 373–388)

      Michael E. Sigman and C. Douglas Clark

  6. Section V: Space Exploration

    1. Chapter 17

      Mass Spectrometry in Solar System Exploration (pages 389–405)

      Paul V. Johnson, Luther W. Beegle and Isik Kanik

    2. Chapter 18

      Application of GC × GC–TOFMS to the Characterization of Extraterrestrial Organic Matter (pages 407–415)

      Jonathan S. Watson

  7. Section VI: Homeland Security

    1. Chapter 19

      Methods of Mass Spectrometry in Homeland Security Applications (pages 417–439)

      Ünige A. Laskay, Erin J. Kaleta and Vicki H. Wysocki

    2. Chapter 20

      Homeland Security (pages 441–475)

      Christina L. Crawford and Herbert H. Hill

    3. Chapter 21

      Mass Spectrometry in Homeland Security (pages 477–489)

      Yasuaki Takada

    4. Chapter 22

      Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer (pages 491–507)

      Gary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham and John E. Olson

    5. Chapter 23

      Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios (pages 509–528)

      R. Steven Pappas

  8. Section VII: Food Analysis

    1. Chapter 24

      Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications (pages 529–558)

      Maciej Stobiecki, Piotr Kachlicki and Henryk Jeleñ

    2. Chapter 25

      Top-Down Proteomic Identification of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS (pages 559–574)

      Clifton K. Fagerquist and Omar Sultan

  9. Section VIII: Environmental

    1. Chapter 26

      Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry (pages 575–592)

      Wolfgang Schwack

    2. Chapter 27

      Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry (pages 593–603)

      Chongzheng Na and Terese M. Olson

    3. Chapter 28

      Proton Transfer Reaction Mass Spectrometry (PTR-MS) (pages 605–630)

      Yujie Wang, Chengyin Shen, Jianquan Li, Haihe Jiang and Yannan Chu

    4. Chapter 29

      Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices (pages 631–644)

      Diana Poli

  10. Section IX: Geological

    1. Chapter 30

      Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions (pages 645–673)

      Simon C. George, Herbert Volk and Adriana Dutkiewicz

    2. Chapter 31

      LA-MC-ICP-MS Applied to U-PB Zircon Geochronology (pages 675–705)

      Alain Cocherie and Michèle Robert

    3. Chapter 32

      Hydrocarbon Processing (pages 707–723)

      Maoqi Feng, Thomas Andrews and Eloy Flores

    4. Chapter 33

      Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples (pages 725–747)

      Alan A. Herod

    5. Chapter 34

      Renewable Energy: Mass Spectrometry in Biofuel Research (pages 749–762)

      Ingvar Eide and Kolbjørn Zahlsen

  11. Section X: Archaeology

    1. Chapter 35

      Mass Spectrometry in Archaeology (pages 763–795)

      Robert Hedges and James McCullagh

    2. Chapter 36

      Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins, Lipids, Terpenoid Resins, Lignocellulosic Polymers, and Dyestuff (pages 797–828)

      Maria Perla Colombini, Francesca Modugno and Erika Ribechini

    3. Chapter 37

      Laser Ablation ICP-MS in Archaeology (pages 829–843)

      Hector Neff

    4. Chapter 38

      Spatially Resolved MS in the Study of Art and Archaeological Objects (pages 845–858)

      Giuseppe Spoto

    5. Chapter 39

      Laser Ablation–Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples (pages 859–883)

      Martín Resano, Esperanza García-Ruiz and Frank Vanhaecke

  12. Section XI: Surface Analysis

    1. Chapter 40

      Mass Spectrometry in Semiconductor Research (pages 885–942)

      Stefan Flege and Wolfgang Ensinger

    2. Chapter 41

      Analysis of thin and thick Films (pages 943–959)

      Philippe Le Coustumer, Patrick Chapon, Agnès Tempez, Yuriy Popov, George Thompson, Igor Molchan, Nicolas Trigoulet, Peter Skeldon, Antonino Licciardello, Nunzio Tuccitto, Ivan Delfanti, Katrin Fuhrer, Marc Gonin, James Whitby, Markus Hohl, Christian Tanner, Nerea Bordel Garcia, Lara Lobo Revilla, Jorge Pisonero, Rosario Pereiro, Cristina Gonzalez Gago, Alfredo Sanz Medel, Mihai Ganciu Petcu, Ani Surmeian, Constantin Diplasu, Andreea Groza, Norbert Jakubowski, Roland Dorka, Stela Canulescu, Johann Michler, Philippe Belenguer, Thomas Nelis, Abdellatif Zahri, Philippe Guillot, Laurent Thérèse, Arnaud Littner, Richard Vaux, Julien Malherbe, Frédéric Huneau, Fred Stevie and Hugues François-Saint-Cyr

    3. Chapter 42

      SIMS for Organic Film Analysis (pages 961–1015)

      Taoufiq Mouhib and Arnaud Delcorte

    4. Chapter 43

      Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of MICA Minerals (pages 1017–1059)

      Luisa Ottolini, Emanuela Schingaro and Fernando Scordari

  13. Section XII: Polymers

    1. Chapter 44

      ETV-ICPMS for Analysis of Polymers (pages 1061–1077)

      Maite Aramendía Marzo, Martín Resano and Frank Vanhaecke

    2. Chapter 45

      Polymers (pages 1079–1105)

      Maurizio S. Montaudo and Salvatore Battiato

    3. Chapter 46

      Mass Spectroscopy in Polymer Research (pages 1107–1133)

      Jale Hacaloglu and Talat Yalcin

    4. Chapter 47

      Laser Mass Spectrometry Applied to the Analysis of Polymers (pages 1135–1141)

      Jérôme Bour and David Ruch

  14. Section XIII: Analytical Techniques

    1. Chapter 48

      Measuring Thermodynamic Properties of Metals and Alloys (pages 1143–1180)

      Evan H. Copland and Nathan S. Jacobson

    2. Chapter 49

      High-Performance Thin-Layer Chromatography–Mass Spectrometry for Analysis of Small Molecules (pages 1181–1206)

      Gertrud E. Morlock

    3. Chapter 50

      Laser Ionization Mass Spectrometry of Inorganic Ions (pages 1207–1227)

      Julius Pavlov and Athula B. Attygalle

    4. Chapter 51

      Mass Spectrometry in the SSITKA Studies (pages 1229–1256)

      L. G. Pinaeva, E. M. Sadovskaya, A. P. Suknev, V. B. Goncharov and B. S. Bal'zhinimaev

    5. Chapter 52

      Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences (pages 1257–1281)

      Elena Crespo, Marco M. L. Steeghs, Simona M. Cristescu and Frans J. M. Harren

    1. You have free access to this content
      Index (pages 1283–1340)

SEARCH