ADME-Enabling Technologies in Drug Design and Development

ADME-Enabling Technologies in Drug Design and Development

Editor(s): Donglu Zhang, Sekhar Surapaneni

Published Online: 15 MAY 2012 09:55PM EST

Print ISBN: 9780470542781

Online ISBN: 9781118180778

DOI: 10.1002/9781118180778

About this Book

A comprehensive guide to cutting-edge tools in ADME research

The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).

ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides:

  • A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones

  • Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies

  • Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies

  • Numerous figures and diagrams throughout the text

Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.

Table of contents

    1. You have free access to this content
  1. Part A: ADME: Overview and Current Topics

  2. Part B: ADME Systems and Methods

  3. Part C: Analytical Technologies

    1. Chapter 24

      Supercritical Fluid Chromatography (pages 363–380)

      Jun Dai, Yingru Zhang, David B. Wang-Iverson and Adrienne A. Tymiak

    2. Chapter 25

      Chromatographic Separation Methods (pages 381–399)

      Wenying Jian, Richard W. Edom, Zhongping (john) Lin and Naidong Weng

    3. Chapter 26

      Mass Spectrometric Imaging for Drug Distribution in Tissues (pages 401–417)

      Daniel P. Magparangalan, Timothy J. Garrett, Dieter M. Drexler and Richard A. Yost

  4. Part D: New and Related Technologies

    1. You have free access to this content
    1. You have free access to this content

SEARCH