Therapeutic Targets: Modulation, Inhibition, and Activation

Therapeutic Targets: Modulation, Inhibition, and Activation

Editor(s): Luis M. Botana, Mabel Loza

Published Online: 29 MAY 2012 09:09AM EST

Print ISBN: 9780470587195

Online ISBN: 9781118185537

DOI: 10.1002/9781118185537

About this Book

The Latest Applications For Cellmechanism Research in Drug Discovery

Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe.

The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more.

Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.

Table of contents

    1. You have free access to this content
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    3. Chapter 9

      Gene Promoters and Transcription Control Regions as Therapeutic Targets (pages 327–350)

      Antonio Zorzano, David Sebastián, Jana Sánchez-Wandelmer, Laia Miret and Fernando Albericio

    4. Chapter 11

      Exocytotic Machinery as a Target for the Development of New Drugs for Schizophrenia (pages 375–408)

      María José Guerrero, Itsaso Hormaeche, María Uribarri, Julie Masse and José María Palacios

    5. You have free access to this content

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