Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro/In Vivo Correlations

Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro/In Vivo Correlations

Editor(s): J. Andrew Williams, Jeffrey R. Koup, Richard Lalonde, David D. Christ

Published Online: 28 FEB 2012 03:22AM EST

Print ISBN: 9780470170830

Online ISBN: 9781118230275

DOI: 10.1002/9781118230275

Series Editor(s): Sean Ekins

About this Book

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers.  Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers.  Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Table of contents

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  1. Part I: Biomarkers in Drug Discovery

  2. Part II: Clinical Application of Biomarkers

  3. Part III: Regulatory Perspectives

    1. Chapter 11

      Use of Biomarker in Drug Development—Japanese Perspectives (pages 269–287)

      Yoshiaki Uyama, Akihiro Ishiguro, Harumasa Nakamura and Satoshi Toyoshima

  4. Part IV: Predicting In Vivo

    1. You have free access to this content
    1. You have free access to this content

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