Telomerases: Chemistry, Biology, and Clinical Applications

Telomerases: Chemistry, Biology, and Clinical Applications

Editor(s): Neal F. Lue, Chantal Autexier

Published Online: 21 MAY 2012 01:55AM EST

Print ISBN: 9780470592045

Online ISBN: 9781118268667

DOI: 10.1002/9781118268667

About this Book

This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research.  Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase.  Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

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