Vaccinology: Principles and Practice

Copyright © 2012 Blackwell Publishing Ltd

Vaccinology: Principles and Practice

Editor(s): W. John W. Morrow, Nadeem A. Sheikh, Clint S. Schmidt, D. Huw Davies

Published Online: 20 JUN 2012 03:25AM EST

Print ISBN: 9781405185745

Online ISBN: 9781118345313

DOI: 10.1002/9781118345313

About this Book

Product Information

About The Product

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

  • Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
  • Includes evaluation of vaccine efficacy and safety
  • Details clinical trial design, including regulatory requirements
  • Discusses the emerging field of active cellular immunotherapy

Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xii)

  2. Part 1: Introduction

    1. Chapter 1

      Concept and Scope of Modern Vaccines (pages 1–11)

      D. Huw Davies, Clint S. Schmidt and Nadeem A. Sheikh

  3. Part 2: Principles of Vaccine Design

    1. Chapter 2

      Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants (pages 13–28)

      Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter and Volker Gerdts

    2. Chapter 3

      Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules (pages 29–46)

      Antony N. Antoniou, Izabela Lenart, David B. Guiliano and Simon J. Powis

    3. Chapter 4

      Understanding the Mucosal Immune System for Better Mucosal Vaccine Design (pages 47–60)

      Janine Bilsborough and Joanne L. Viney

    4. Chapter 5

      Immunologic Memory: T Cells in Humans (pages 61–78)

      Maria Candela Iglesias, Victor Appay and Arnaud Moris

    5. Chapter 6

      Immunologic Memory: B cells (pages 79–93)

      F. Eun-Hyung Lee and Iñaki Sanz

    6. Chapter 7

      Utility of Mouse Models in Vaccine Design and Development (pages 94–109)

      Catharine M. Bosio, Megan MacLeod, Philippa Marrack and Ross M. Kedl

    7. Chapter 8

      Utility of Nonhuman Primate Models for Vaccines (pages 110–130)

      Preston A. Marx and Alexander F. Voevodin

  4. Part 3: Antigen Discovery

    1. Chapter 9

      Sequence-Based Computational Approaches to Vaccine Discovery and Design (pages 131–149)

      Darrick Carter

    2. Chapter 10

      Antigen Discovery for Vaccines Using High-Throughput Proteomic Screening Technologies (pages 150–167)

      D. Huw Davies

    3. Chapter 11

      Phage Libraries (pages 168–178)

      Aaron K. Sato

  5. Part 4: Antigen Engineering

    1. Chapter 12

      Attenuated Bacterial Vaccines (pages 179–195)

      Richard W. Titball and Helen S. Atkins

    2. Chapter 13

      Virus-Like Particles as Antigen Scaffolds (pages 196–208)

      Bryce Chackerian and John T. Schiller

    3. Chapter 14

      Recombinant MVA vaccines: Optimization, Preclinical, and Product Development (pages 209–223)

      Yper Hall and Miles W. Carroll

    4. Chapter 15

      Recombinant Adenoviruses for Vaccination (pages 224–236)

      Nelson Cesar Di Paolo, Dmitry Shayakhmetov and André Lieber

    5. Chapter 16

      Recombinant Avipoxviruses (pages 237–254)

      Michael A. Skinner and Stephen M. Laidlaw

    6. Chapter 17

      Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy (pages 255–274)

      Patrick Guirnalda, Laurence Wood, Matthew Seavey and Yvonne Paterson

    7. Chapter 18

      Nucleic Acid Vaccination (pages 275–285)

      Britta Wahren and Margaret A. Liu

    8. Chapter 19

      Artificial Antigen-Presenting Cells: Large Multivalent Immunogens (pages 286–299)

      Matthew F. Mescher and Julie M. Curtsinger

  6. Part 5: Delivery Systems

    1. Chapter 20

      Transcutaneous Immunization via Vaccine Patch Delivery System (pages 301–323)

      Robert C. Seid and Gregory M. Glenn

    2. Chapter 21

      Needle-Free Jet Injection for Vaccine Administration (pages 324–335)

      Brian R. Sloat, Hoi K. Tran and Zhengrong Cui

    3. Chapter 22

      Oral Vaccines: An Old Need and Some New Possibilities (pages 336–347)

      Amit A. Lugade, Kalathil Suresh and Yasmin Thanavala

    4. Chapter 23

      Adjuvants: From Serendipity to Rational Discovery (pages 348–360)

      Derek T. O'Hagan and Andreas Wack

    5. Chapter 24

      Immunostimulatory Properties of Biodegradable Microparticles (pages 361–374)

      Fiona A. Sharp and Ed C. Lavelle

    6. Chapter 25

      Co-Administration of Co-Stimulatory Moieties (pages 375–392)

      Carolina Arancibia-Cárcamo and Yvette Latchman

    7. Chapter 26

      Toll Receptors in Relation to Adjuvant Effects (pages 393–400)

      Dipshikha Chakravortty, Amit Lahiri and Priyanka Das

  7. Part 6: Regulatory Considerations

    1. Chapter 27

      Regulatory Issues (FDA and EMA) (pages 401–415)

      Murrium Ahmad, Victoria Byers and Peter Wilson

  8. Part 7: Evaluating Vaccine Efficacy

    1. Chapter 28

      Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine (pages 417–440)

      Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton and Camilla Jandus

    2. Chapter 29

      Clinical Development Strategy: Nuts and Bolts (pages 441–451)

      Candida Fratazzi and Claudio Carini

    3. Chapter 30

      Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification (pages 452–463)

      Robert Rees, Stephanie Laversin, Cliff Murray and Graham Ball

  9. Part 8: Implementing Immunizations/Therapies

    1. Chapter 31

      Mass Immunization Strategies (pages 465–479)

      David L. Heymann, R. Bruce Aylward and Rudolf H. Tangermann

    2. Chapter 32

      The Role of Mathematical Models in Vaccine Development and Public Health Decision Making (pages 480–508)

      Marie-Claude Boily, Marc Brisson, Benoit Mâsse and Roy M. Anderson

    3. Chapter 33

      Vaccine Safety (pages 509–524)

      John Iskander, Claudia Vellozzi, Jane Gidudu and Robert T. Chen

    1. You have free access to this content
      Index (pages 525–540)

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