Toxicology and Epigenetics

Toxicology and Epigenetics

Editor(s): Saura C. Sahu

Published Online: 8 AUG 2012 02:35AM EST

Print ISBN: 9781119976097

Online ISBN: 9781118349045

DOI: 10.1002/9781118349045

About this Book

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:

  • environment, epigenetics and diseases
  • DNA methylation and toxicogenomics
  • chromatin at the intersection of disease and therapy
  • epigenomic actions of environmental arsenicals
  • environment, epigenetics and cardiovascular health
  • toxicology, epigenetics and autoimmunity
  • ocular epigenomics: potential sites of environmental impact in development and disease
  • nuclear RNA silencing and related phenomena in animals
  • epigenomics - impact for drug safety sciences
  • methods of global epigenomic profiling
  • transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Molecular Epigenetic Changes Caused by Environmental Pollutants (pages 73–109)

      Solange S. Lewis, Gregory J. Weber, Jennifer L. Freeman and Maria S. Sepúlveda

    3. Chapter 19

      Epigenomics – Impact for Drug Safety Sciences (pages 365–385)

      Harri Lempiäinen, Raphaëlle Luisier, Arne Müller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs and Rémi Terranova

    4. Chapter 22

      Methods of Global Epigenomic Profiling (pages 427–443)

      Michael W. Y. Chan, Zhengang Peng, Jennifer Chao Weber, Ying-Wei Li, Matthew T. Zuzolo and Huey-Jen L. Lin

    5. You have free access to this content
    6. You have free access to this content