Cancer Stem Cells

Copyright © 2014 John Wiley & Sons, Inc.

Cancer Stem Cells

Editor(s): Vinagolu K. Rajasekhar

Published Online: 31 JAN 2014 09:52PM EST

Print ISBN: 9781118356166

Online ISBN: 9781118356203

DOI: 10.1002/9781118356203

About this Book

Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic.

Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xxxv)

  2. Part I: Essentials of Cancer Stem Cells and Conceptual Modeling

    1. Chapter 1

      Theoretical and Experimental Foundations of the “Cancer Stem Cell” Model (pages 1–16)

      Pradeep S. Rajendran and Piero Dalerba

    1. Chapter 2

      The Hallmarks of Prostate Cancer Stem Cells (pages 17–37)

      Norman J. Maitland and Anne T. Collins

    1. Chapter 3

      Self-Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication (pages 39–47)

      Dov Zipori

    1. Chapter 4

      Human Embryonic Stem Cells and Cancer (pages 49–60)

      Tamra Werbowetski-Ogilvie and Robyn McClelland

    1. Chapter 5

      Cancer Stem Cell as a Result of a Reprogramming-Like Mechanism (pages 61–77)

      J.M. Iglesias, Idoia García-Ramírez, Alberto Martín-Lorenzo, L. Vellon, Lucia Ruiz-Roca, A.G. Martin and Isidro Sanchez-Garcia

    1. Chapter 6

      A Cancer Stem Cell Model (pages 79–87)

      Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu and Masaharu Seno

    1. Chapter 7

      Altruistic Stem Cells and Cancer Stem Cells (pages 89–105)

      Bikul Das

    1. Chapter 8

      The Emerging Concept of EMT-Induced Cancer Stem Cells (pages 107–117)

      Jeremy Bastid

    1. Chapter 9

      Models to Study Chronic Myeloid Leukemia Cancer Stem Cells (pages 119–131)

      Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, Steffen Koschmieder, Anthony D. Whetton and Tessa L. Holyoake

    1. Chapter 10

      Cancer Stem Cells in Melanoma (pages 133–141)

      Stefano Zapperi and Caterina A.M. La Porta

  12. Part II: Stem Cells in Liquid Tumors

    1. Chapter 11

      Acute Myeloid Leukemia Stem Cells—Updates and Controversies (pages 143–160)

      Stephen S. Chung and Christopher Y. Park

    1. Chapter 12

      Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia (pages 161–170)

      Thorsten Raff and Monika Brüggemann

  14. Part III: Stem Cells in Solid Tumors

    1. Chapter 13

      Lung Cancer Stem Cells and Resistance to Radiotherapy (pages 171–182)

      Scott V. Bratman and Maximilian Diehn

    1. Chapter 14

      Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells (pages 183–191)

      Mark A. Badeaux and Dean G. Tang

    1. Chapter 15

      Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse (pages 193–208)

      Aneet Mann, Randy van Ommeren, Branavan Manoranjan, Nicole McFarlane, Parvez Vora, Chitra Venugopal and Sheila Singh

    1. Chapter 16

      Stem Cells and Pancreatic Cancer (pages 209–222)

      Susana García-Silva and Christopher Heeschen

    1. Chapter 17

      Melanoma Subpopulations with Cancer Stem Cell Phenotypes (pages 223–234)

      Rajasekharan Somasundaram, Nicole Facompre and Meenhard Herlyn

    1. Chapter 18

      Sarcoma Stem Cells (pages 235–245)

      Filemon S. Dela Cruz and Igor Matushansky

  20. Part IV: Cancer Stem Cells in Tumor Metastasis Perspective

    1. Chapter 19

      Cancer Stem Cells in Metastasis and Minimal Residual Disease (pages 247–258)

      Joerg Huelsken and Albert Santamaria i Martínez

    1. Chapter 20

      Role of Cancer Stem Cells in Metastasis (pages 259–271)

      Giovanna Merchand-Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell and Marco Velasco-Velázquez

    1. Chapter 21

      Cancer Stem Cells and the Stromal Microenvironment (pages 273–286)

      Li Li and David A. Margolin

    1. Chapter 22

      A Perspective on Breast Cancer Malignant Progression (pages 287–294)

      Pasquale Sansone, Vinagolu K. Rajasekhar and Jacqueline Bromberg

  24. Part V: Novel and Potential Targets in Cancer Stem Cells

    1. Chapter 23

      Targeting Cancer Stem Cells—Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism (pages 295–317)

      Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S. Percy Ivy and Hideyuki Saya

    1. Chapter 24

      Oct4, Oct1, and Cancer Stem Cells (pages 319–329)

      Jessica Maddox and Dean Tantin

    1. Chapter 25

      The Role of Cripto-1 in Cancer and Cancer Stem Cells (pages 331–345)

      Hideaki Karasawa, Nadia P. Castro, Maria Cristina Rangel and David S. Salomon

    1. Chapter 26

      Leptin Signaling in the Regulation of Stem and Cancer Stem Cells (pages 347–360)

      Shanchun Guo, Keshav K. Singh, James W. Lillard and Lily Yang

    1. Chapter 27

      Tumor-Initiating Stem-Like Cells (pages 361–372)

      Keigo Machida

    1. Chapter 28

      The Role of Epithelial Cell Polarity Pathways on Cancer Stem Cells (pages 373–388)

      Inmaculada Bañón-Rodríguez, Ilenia Bernascone and Fernando Martín-Belmonte

    1. Chapter 29

      Cancer-Initiating Cells, Exosomes, and the Premetastatic Niche (pages 389–402)

      Margot Zöller

    1. Chapter 30

      MicroRNA Therapeutics to Target Brain Tumor Stem Cells (pages 403–415)

      Derryn Xin Hui Chan, Srikanth Nama, Gopinath Sundaram and Prabha Sampath

    1. Chapter 31

      The Riboproteome Orchestrates Self-Renewal and Cell Fate in Leukemia (pages 417–434)

      Elianna M. Amin and Michael G. Kharas

  33. Part VI: Clinical Relevance of Cancer Stem Cells in Patients

    1. Chapter 32

      Targeting Different States of Breast Cancer Stem Cells (pages 435–450)

      Sean P. McDermott and Max S. Wicha

    1. Chapter 33

      Difficulties in Targeting the Beating Heart (pages 451–460)

      Jennifer Makalowski and Hinrich Abken

    1. Chapter 34

      Targeting Cancer Stem Cells for Overcoming Drug Resistance and Cancer Progression (pages 461–471)

      Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao and Fazlul H. Sarkar

    1. Chapter 35

      The Role of Cancer Stem Cells in Tumor Radioresistance (pages 473–491)

      I. Kurth, C. Peitzsch, M. Baumann and A. Dubrovska

    1. You have free access to this content
      Index (pages 493–508)

    1. You have free access to this content
      Supplemental Images (pages a–ff)

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