Production of Plasma Proteins for Therapeutic Use

Production of Plasma Proteins for Therapeutic Use

Editor(s): Joseph Bertolini, Neil Goss, John Curling

Published Online: 14 DEC 2012 11:42AM EST

Print ISBN: 9780470924310

Online ISBN: 9781118356807

DOI: 10.1002/9781118356807

About this Book

Sets forth the state of the science and technology in plasma protein production

With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential.

Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections:

  • Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry.
  • Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses.
  • Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission.
  • Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products.
  • Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.

Table of contents

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  1. Section 1: Introduction to Plasma Fractionation

  2. Section 2: Plasma Proteins for Therapeutic Use

    1. Chapter 6

      Factor IX (pages 81–92)

      Salvador Grancha, Steven Herring, Antonio Paéz, Pere Ristol and Juan Ignacio Jorquera

    2. Chapter 14

      Hyperimmune Immunoglobulin G (pages 207–216)

      Hugh Price, Maurice Genereux and Christopher Sinclair

    3. Chapter 15

      Rh (D) Immunoglobulin (pages 217–225)

      Maurice Genereux, Jodi Smith, William Bees and Christopher Sinclair

    4. Chapter 17

      C1-Inhibitor (pages 241–258)

      Jan Over, Christine Kramer, Anky Koenderman, Diana Wouters and Sacha Zeerleder

    5. Chapter 21

      Transferrin (pages 301–310)

      Leni von Bonsdorff, Hennie ter Hart, Ingrid Prins-De Nijs, Anky Koenderman, Jan Over and Jaakko Parkkinen

    6. Chapter 25

      Solvent/Detergent Plasma (pages 345–357)

      Tor-Einar Svae, Andrea Heger, Lothar Biesert, Andrea Neisser-Svae and Wolfgang Frenzel

  3. Section 3: Pathogen Safety of Plasma Products

  4. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation

  5. Section 5: The Market for Plasma Products and the Economics of Fractionation

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