Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

Editor(s): Natanya Civjan

Published Online: 10 AUG 2012 08:09AM EST

Print ISBN: 9781118101186

Online ISBN: 9781118435762

DOI: 10.1002/9781118435762

About this Book

An authoritative look at the application of chemical biology in drug discovery and development

Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.

Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:

  • The design, development, and optimization of drug candidates
  • The pharmacokinetics and properties of drugs
  • Drug transport and delivery
  • Natural products and natural product models as pharmaceuticals
  • Biological mechanisms underlying health and disease
  • Treatment strategies for a range of diseases, from HIV to schizophrenia

Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Table of contents

    1. You have free access to this content
  1. Part I: Drug Discovery and Development

    1. Chapter 2

      Computational Approaches to Drug Discovery and Development (pages 23–40)

      Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu and Hualiang Jiang

    2. Chapter 4

      Lead Optimization in Drug Discovery (pages 65–81)

      Craig W. Lindsley, David Weaver, Thomas M. Bridges and J. Phillip Kennedy

  2. Part II: Chemical Biology to Understand and Target Disease

    1. Chapter 15

      Osteoarthritis (pages 293–329)

      Marjolaine Gosset, Jérémie Sellam, Claire Jacques and Francis Berenbaum

    2. Chapter 19

      Protein Misfolding and Disease (pages 379–400)

      Johanna C. Scheinost, Grant E. Boldt and Paul Wentworth

    1. You have free access to this content

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