Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

Editor(s): Stefan Hoppler, Randall T. Moon

Published Online: 7 MAR 2014 09:58PM EST

Print ISBN: 9781118444160

Online ISBN: 9781118444122

DOI: 10.1002/9781118444122

About this Book

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network.

• A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.

• Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases

• Reviews the complex processes of signal integration and regulation

• Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway's role in diseases and potential clinical applications.

Table of contents

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  1. Part 1: Molecular Signaling Mechanisms: From Pathways to Networks

    1. Chapter 3

      Wnt Signal Transduction in the Cytoplasm (pages 33–49)

      Tony W. Chen, Heather A. Wallace, Yashi Ahmed and Ethan Lee

    1. Chapter 11

      Mathematical Models of Wnt Signaling Pathways (pages 153–160)

      Michael Kühl, Barbara Kracher, Alexander Groß and Hans A. Kestler

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  2. Part 2: Selected Key Molecules in Wnt Signaling

    1. Chapter 13

      Secreted Wnt Inhibitors or Modulators (pages 177–193)

      Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve and Herbert Steinbeisser

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  3. Part 3: Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis

    1. Chapter 24

      Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis (pages 315–328)

      Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker and Elizabeth Vincan

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  4. Part 4: Wnt Signaling in Chronic Disease

    1. Chapter 29

      Wnt Signaling in Mood and Psychotic Disorders (pages 379–391)

      Stephen J. Haggarty, Karun Singh, Roy H. Perlis and Rakesh Karmacharya

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