Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Editor(s): Dennis Douroumis, Alfred Fahr

Published Online: 4 FEB 2013 06:06AM EST

Print ISBN: 9780470711972

Online ISBN: 9781118444726

DOI: 10.1002/9781118444726

About this Book

Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of
techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies.

Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self-microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical
formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues.

Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug
delivery, polymers and biomaterials.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs (pages 151–197)

      Naveed Ahmed, C.E. Mora-Huertas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari

    3. Chapter 14

      Polymeric Micelles for the Delivery of Poorly Soluble Drugs (pages 411–476)

      Swati Biswas, Onkar S. Vaze, Sara Movassaghian and Vladimir P. Torchilin

    4. You have free access to this content
    5. You have free access to this content

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