The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, Second Edition

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, Second Edition

Editor(s): André Merbach, Lothar Helm, Éva Tóth

Published Online: 18 FEB 2013 09:11PM EST

Print ISBN: 9781119991762

Online ISBN: 9781118503652

DOI: 10.1002/9781118503652

About this Book

Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement.

This completely revised and extended second edition: 

  • Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents.
  • Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations.
  • Is written for all of those involved in the development and application of contrast agents in MRI.
  • Presented in colour, it provides readers with true representation and easy interpretation of the images. 

A word from the Authors:

Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms.

Reviews of the First Edition:

"...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."-Journal of the American Chemical Society

Table of contents

    1. You have free access to this content
    2. Chapter 1

      General Principles of MRI (pages 1–23)

      Bich-Thuy Doan, Sandra Meme and Jean-Claude Beloeil

    3. Chapter 4

      Stability and Toxicity of Contrast Agents (pages 157–208)

      Ern˜o Brücher, Gyula Tircsó, Zsolt Baranyai, Zoltán Kovács and A. Dean Sherry

    4. Chapter 5

      Structure, Dynamics, and Computational Studies of Lanthanide-Based Contrast Agents (pages 209–276)

      Joop A. Peters, Kristina Djanashvili, Carlos F. G. C. Geraldes and Carlos Platas-iglesias

    5. Chapter 8

      Responsive Probes (pages 343–385)

      Célia S. Bonnet, Lorenzo Tei, Mauro Botta and éva Tóth

    6. You have free access to this content

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