Lysophospholipid Receptors: Signaling and Biochemistry

Lysophospholipid Receptors: Signaling and Biochemistry

Editor(s): Jerold Chun, Timothy Hla, Sara Spiegel, Wouter Moolenaar

Published Online: 19 FEB 2013 09:48AM EST

Print ISBN: 9780470569054

Online ISBN: 9781118531426

DOI: 10.1002/9781118531426

About this Book

The current state of the science supporting new research in lysophospholipids

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.

Lysophospholipid Receptors is divided into three sections:

  • Receptors and other possible effectors
  • Enzymes
  • Physiology and pathophysiology

Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.

Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Table of contents

    1. You have free access to this content
    2. Chapter 9

      Sphingosine Kinases: Biochemistry, Regulation, and Roles (pages 153–183)

      Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham and Stuart M. Pitson

    3. Chapter 13

      Lysophosphatidic Acid (LPA) Signaling and Cardiovascular Pathology (pages 265–281)

      Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam and Andrew J. Morris

    4. Chapter 21

      Role of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders (pages 451–473)

      Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega and Fernando Rodríguez de Fonseca

    5. Chapter 23

      Biology Revealed by Sphingosine 1-Phosphate (S1P) Receptor Gene-Altered Mice (pages 489–506)

      Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner and Richard L. Proia

    6. Chapter 28

      Lysophosphatidic Acid (LPA) Signaling and Bone (pages 609–625)

      Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol, Fabienne Briand-Mésange and Isabelle Gennero

    7. Chapter 29

      Lysophosphatidic Acid (LPA) Signaling and Bone Cancer (pages 627–640)

      Olivier Peyruchaud, Marion David, Timothy L. Macdonald and Kevin R. Lynch

    8. Chapter 33

      Clinical Introduction of Lysophosphatidic Acid (LPA) and Autotaxin Assays (pages 709–735)

      Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda and Junken Aoki

    9. Chapter 34

      Antibodies to Bioactive Lysophospholipids (pages 737–751)

      Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney and Barbara Visentin

    10. You have free access to this content