Replacing Animal Models: A Practical Guide to Creating and Using Culture-Based Biomimetic Alternatives

Replacing Animal Models: A Practical Guide to Creating and Using Culture-Based Biomimetic Alternatives

Editor(s): Jamie Davies

Published Online: 27 MAR 2012 02:24AM EST

Print ISBN: 9780470974254

Online ISBN: 9781119940685

DOI: 10.1002/9781119940685

About this Book

Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments.

The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing.

The thesis of this book is not that all animal experimentation can be replaced, now or in the near future, by equally effective or superior alternatives. Rather, the premise is that there is substantial opportunity, here and now, to do some common types of experiment better in vitro than in vivo, and that doing so will result in both scientific and ethical gains.

Table of contents

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    1. You have free access to this content
  1. Section 1: Introductory Material

  2. Section 2: Culture Methods

    1. Chapter 5

      Modelling Lymphatic and Blood Capillary Patterning (pages 45–56)

      Françoise Bruyère, Catherine Maillard, Charlotte Erpicum and Agnès Noël

  3. Section 3: Case Studies of Use

    1. You have free access to this content
    1. You have free access to this content
    1. You have free access to this content

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