Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2

Editor(s): John Whittall, Peter W. Sutton

Published Online: 13 MAY 2012 09:43PM EST

Print ISBN: 9781119991397

Online ISBN: 9781119943426

DOI: 10.1002/9781119943426

About this Book

Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities.

Practical Methods for Biocatalysis and Biotransformations 2 is a "how-to" guide that focuses on the practical applications of enzymes and strains of microorganisms that are readily obtained or derived from culture collections. The sources of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given and relevant references to the primary literature are cited. This second volume - which can be used on its own or in combination with the first volume - concentrates on new applications and new enzyme families reported since the first volume. Contents include:

  • introduction to recent developments and future needs in biocatalysts and synthetic biology in industry
  • reductive amination
  • enoate reductases for reduction of electron deficient alkenes
  • industrial carbonyl reduction
  • regio- and stereo- selective hydroxylation
  • oxidation of alcohols
  • selective oxidation
  • industrial hydrolases and related enzymes
  • transferases for alkylation, glycosylation and phosphorylation
  • C-C bond formation and decarboxylation
  • halogenation/dehalogenation/heteroatom oxidation
  • tandem and sequential multi-enzymatic syntheses

Practical Methods for Biocatalysis and Biotransformations 2 is an essential collection of biocatalytic methods for chemical synthesis which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.

Table of contents

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    2. Chapter 1

      Biocatalysis in the Fine Chemical and Pharmaceutical Industries (pages 1–59)

      Peter W. Sutton, Joseph P. Adams, Ian Archer, Daniel Auriol, Manuela Avi, Cecilia Branneby, Andrew J. Collis, Bruno Dumas, Thomas Eckrich, Ian Fotheringham, Rob ter Halle, Steven Hanlon, Marvin Hansen, K. E. Holt-Tiffin, Roger M. Howard, Gjalt W. Huisman, Hans Iding, Kurt Kiewel, Matthias Kittelmann, Ernst Kupfer, Kurt Laumen, Fabrice Lefèvre, Stephan Luetz, David P. Mangan, Van A. Martin, Hans-Peter Meyer, Thomas S. Moody, Antonio Osorio-Lozada, Karen Robins, Radka Snajdrova, Matthew D. Truppo, Andrew Wells, Beat Wirz and John W. Wong

    3. Chapter 2

      Reductive Amination (pages 61–86)

      Simon Willies, Matthew D. Truppo, Christopher K. Savile, Jacob M. Janey, Jeffrey C. Moore, Gjalt W. Huisman, Gregory J. Hughes, Francesco G. Mutti, Christine S. Fuchs, Wolfgang Kroutil, Jennifer Hopwood, Matthew D. Truppo, Richard Lloyd, Nicholas J. Turner, Eun Young Hong, Minho Cha, Hyungdon Yun, Byung-Gee Kim, S. Stella and Anju Chadha

    4. Chapter 3

      Enoate Reductases for Reduction of Electron Deficient Alkenes (pages 87–114)

      Mélanie Hall, Christoph K. Winkler, Gábor Tasnádi, Kurt Faber, Elisabetta Brenna, Francesco G. Gatti, Fabio Parmeggiani, Pietro Buzzini, Marta Goretti, Chiara Ponzoni, Elisa Caselli, Eva Branda, Maria Rita Cramarossa, Benedetta Turchetti, Luca Forti, Adam Z. Walton, Bradford T. Sullivan, Jon D. Stewart, Maximiliano A. Sortino and Susana A. Zacchino

    5. Chapter 4

      Industrial Carbonyl Reduction (pages 115–127)

      David P. Mangan, Thomas S. Moody, Owen Gooding, Gjalt W. Huisman, Carlos A. Martinez, Adam Smogowicz, Jeremy S. Steflik, Maria S. Brown, Katarina S. Midelfort, Michael P. Burns, John W. Wong and Jack Liang

    6. Chapter 5

      Regio- and Stereoselective Hydroxylation (pages 129–162)

      Marcus Hans, Jan-Metske van der Laan, Ben Meijrink, Wibo van Scheppingen, Richard Kerkman, Marco van den Berg, Matthias Kittelmann, Anton Kuhn, Annina Riepp, Jürgen Kühnöl, Andreas Fredenhagen, Lukas Oberer, Oreste Ghisalba, Stephan Luetz, David P. Mangan, Thomas S. Moody, David Schmid, Antonio Osorio-Lozada, F. Özde. Ütkür, Jonathan Collins, Christoph Brandenbusch, Gabriele Sadowski, Andreas Schmid, Bruno Bühler, Matthias Kinne, Marzena Poraj-Kobielska, René Ullrich, Martin Hofrichter, Gideon Grogan and Mark L. Thompson

    7. Chapter 6

      Oxidation of Alcohols (pages 163–179)

      Rajesh Kumar, Jim Cawley, Michael Karmilowicz, Carlos A. Martinez, Nathan Wymer, Bo Yuan, Franck Escalettes, Nicholas J. Turner, Johann H. Sattler, Katharina Tauber, Francesco G. Mutti and Wolfgang Kroutil

    8. Chapter 7

      Selective Oxidation (pages 181–202)

      Valentin Köhler, Bas Groenendaal, Kevin R. Bailey, Anass Znabet, James Raferty, Madeleine Helliwell, Nicholas J. Turner, Kristian Geitner, Uwe T. Bornscheuer, Gonzalo de Gonzalo, Vicente Gotor, Shuvendu Das, John P. N. Rosazza, Aashrita Rajagopalan, Francesco G. Mutti and Wolfgang Kroutil

    9. Chapter 8

      Industrial Hydrolases and Related Enzymes (pages 203–229)

      Mark Dow, Rebecca Meadows, Rhona Sinclair, Andrew Wells, Gary Breen, John Carey, Fiona Rawlinson, K. E. Holt-tiffin, M. C. Lloyd, Beat Wirz, Paul Spurr, Christophe Pfleger, Graham Checksfield, Stewart T. Hayes, Wilfried Hoffmann, Christian T. Regius, Gemma Scotney, Sarah L. Spencer, Roger M. Howard, Colin M. Burns, Gordon B. Ward, Robert Walton, Neil Barnwell, Matthew D. Truppo and Gregory J. Hughes

    10. Chapter 9

      Transferases for Alkylation, Glycosylation and Phosphorylation (pages 231–262)

      Daniel Auriol, Rob ter Halle, Fabrice Lefèvre, Daniel F. Visser, Gregory E. R. Gordon, Moira L. Bode, Kgama Mathiba, Dean Brady, Karel De Winter, Tom Desmet, An Cerdobbel, Wim Soetaert, Teunie van Herk, Aloysius F. Hartog, Ron Wever, Małgorzata Brzezińska-rodak, Magdalena Klimek-Ochab, Ewa Żymańczyk-Duda, Joyeeta Mukherjee, Munishwar N. Gupta, Wen-Bing Yin, Shu-Ming Li and Mandana Gruber-Khadjawi

    11. Chapter 10

      C–C Bond Formation and Decarboxylation (pages 263–295)

      Alessandra Bonamore, Alberto Macone, Wolfgang Kroutil, Birgit Seisser, Tijs M. Lammens, Daniela De Biase, Maurice C. R. Franssen, Elinor L. Scott, Johan P. M. Sanders, Kenji Miyamoto, Robert Kourist, Shosuke Yoshida, Hiromichi Ohta, Jie Tian, Heng Li, Wen-Yun Gao, Saravanakumar Shanmuganathan, Dessy Natalia, Lasse Greiner, Pablo Domínguez de María, Yan-Hong He, Zhi Guan and Jian-Feng Cai

    12. Chapter 11

      Halogenation/Dehalogenation/Heteroatom Oxidation (pages 297–312)

      Jia Zeng, Jixun Zhan, Zbynek Prokop, Veronika Stepankova, Khomaini Hasan, Radka Chaloupkova, Jiri Damborsky, Ai-Tao Li, Gao-Wei Zheng, Hui-Lei Yu, Jiang Pan, Chun-Xiu Li, Jian-He Xu, Marian Mikołajczyk, Jerzy łuczak and Piotr Kiełbasiński

    13. Chapter 12

      Tandem and Sequential Multi-Enzymatic Syntheses (pages 313–345)

      Bong-Gyu Kim, Joong-Hoon Ahn, Guido Sello, Patrizia Di Gennaro, Teunie van Herk, Aloysius F. Hartog, Ron Wever, Isabel Oroz-Guinea, Israel Sánchez-Moreno, Eduardo García-Junceda, Bian Wu, Wiktor Szymanski, Ben L. Feringa, Dick B. Janssen, Ly Villo, Malle Kreen, Marina Kudryashova, Andrus Metsala, Sven Tamp, ülo Lille, Tõnis Pehk, Omar Parve, Kathleen McClean and Peter Eddowes

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    15. You have free access to this content

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