Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics

Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics

Editor(s): Bruno Sarmento, José das Neves

Published Online: 17 FEB 2012 01:26AM EST

Print ISBN: 9780470978320

Online ISBN: 9781119962977

DOI: 10.1002/9781119962977

About this Book

Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs.

Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential.

Topics covered include:

  • chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals
  • physical properties of chitosan and derivatives in sol and gel states
  • absorption promotion properties of chitosan and derivatives
  • biocompatibility and biodegradation of chitosan and derivatives
  • biological and pharmacological activity of chitosan and derivatives
  • biological, chemical and physical compatibility of chitosan and biopharmaceuticals
  • approaches for functional modification or crosslinking of chitosan
  • use of chitosan and derivatives in conventional biopharmaceutical dosage forms
  • manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals
  • chitosan and derivatives for biopharmaceutical use: mucoadhesive properties
  • chitosan-based systems for mucosal delivery of biopharmaceuticals
  • chitosan-based delivery systems for mucosal vaccination
  • chitosan-based nanoparticulates for oral delivery of biopharmaceuticals
  • chitosan-based systems for ocular delivery of biopharmaceuticals
  • chemical modification of chitosan for delivery of DNA and siRNA
  • target-specific chitosan-based nanoparticle systems for nucleic acid delivery
  • functional PEGylated chitosan systems for biopharmaceuticals
  • stimuli-sensitive chitosan-based systems for biopharmaceuticals
  • chitosan copolymers for biopharmaceuticals
  • application of chitosan for anti-cancer biopharmaceutical delivery
  • chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine
  • wound healing properties of chitosan and its use in wound dressing biopharmaceuticals
  • toxicological properties of chitosan and derivatives for biopharmaceutical applications
  • regulatory status of chitosan and derivatives
  • patentability and intellectual property issues
  • quality control and good manufacturing practice
  • preclinical and clinical use of chitosan and derivatives for biopharmaceuticals

Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.

Table of contents

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  1. Part One: General Aspects of Chitosan

    1. Chapter 4

      Biocompatibility and Biodegradation of Chitosan and Derivatives (pages 57–73)

      Ahmad Sukari Halim, Lim Chin Keong, Ismail Zainol and Ahmad Hazri Abdul Rashid

    2. Chapter 5

      Biological and Pharmacological Activity of Chitosan and Derivatives (pages 75–92)

      Teresa Cunha, Branca Teixeira, Bárbara Santos, Marlene Almeida, Gustavo Dias and José das Neves

    3. Chapter 6

      Biological, Chemical, and Physical Compatibility of Chitosan and Biopharmaceuticals (pages 93–106)

      Masayuki Ishihara, Masanori Fujita, Satoko Kishimoto, Hidemi Hattori and Yasuhiro Kanatani

    4. Chapter 7

      Approaches for Functional Modification or Cross-Linking of Chitosan (pages 107–124)

      A. Anitha, N. Sanoj Rejinold, Joel D. Bumgardner, Shanti V. Nair and Rangasamy Jayakumar

  2. Part Two: Biopharmaceuticals Formulation and Delivery Aspects Using Chitosan and Derivatives

    1. Chapter 15

      Chemical Modification of Chitosan for Delivery of DNA and siRNA (pages 255–273)

      You-Kyoung Kim, Hu-Lin Jiang, Ding-Ding Guo, Yun-Jaie Choi, Myung-Haing Cho, Toshihiro Akaike and Chong-Su Cho

  3. Part Three: Advanced Application of Chitosan and Derivatives for Biopharmaceuticals

    1. Chapter 19

      Chitosan Copolymers for Biopharmaceuticals (pages 333–380)

      Ramon Novoa-Carballal, Ricardo Riguera and Eduardo Fernandez-Megia

    2. Chapter 20

      Application of Chitosan for Anticancer Biopharmaceutical Delivery (pages 381–392)

      Claudia Philippi, Brigitta Loretz, Ulrich F. Schaefer and Claus-Michael Lehr

  4. Part Four: Regulatory Status, Toxicological Issues, and Clinical Perspectives

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