Handbook of Statistical Systems Biology

Handbook of Statistical Systems Biology

Editor(s): Michael P. H. Stumpf, David J. Balding, Mark Girolami

Published Online: 12 SEP 2011

Print ISBN: 9780470710869

Online ISBN: 9781119970606

DOI: 10.1002/9781119970606

About this Book

Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters.

This book:

  • Provides a comprehensive account of inference techniques in systems biology.
  • Introduces classical and Bayesian statistical methods for complex systems.
  • Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems.
  • Discusses various applications for statistical systems biology, such as gene regulation and signal transduction.
  • Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies.
  • Presents an in-depth presentation of reverse engineering approaches.
  • Provides colour illustrations to explain key concepts.

This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.

Table of contents

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  1. Part A: Methodological Chapters

    1. Chapter 3

      Bayesian Inference and Computation (pages 39–65)

      Christian P. Robert, Jean-Michel Marin and Judith Rousseau

  2. Part B: Technology-Based Chapters

  3. Part C: Networks and Graphical Models

    1. Chapter 15

      Modelling Biological Networks via Tailored Random Graphs (pages 309–329)

      Anthony C. C. Coolen, Franca Fraternali, Alessia Annibale, Luis Fernandes and Jens Kleinjung

  4. Part D: Dynamical Systems

  5. Part E: Application Areas

    1. Chapter 22

      Modelling Transcription Factor Activity (pages 440–450)

      Martino Barenco, Daniel Brewer, Robin Callard and Michael Hubank

    2. Chapter 24

      Bayesian Approaches for Mass Spectrometry-Based Metabolomics (pages 467–476)

      Simon Rogers, Richard A. Scheltema, Michael Barrett and Rainer Breitling

    1. You have free access to this content