Current and Future Issues in Hemophilia Care

Copyright © 2011 John Wiley & Sons Ltd

Current and Future Issues in Hemophilia Care

Editor(s): Emérito-Carlos Rodríguez-Merchán, Leonard A. Valentino

Published Online: 12 MAY 2011 09:23AM EST

Print ISBN: 9780470670576

Online ISBN: 9781119979401

DOI: 10.1002/9781119979401

About this Book

Product Information

About The Product

As haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons - have specialized knowledge.
This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the field of haemophilia.

 

Table of contents

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      Front Matter (pages i–xii)

  2. Part 1: Introduction

    1. Chapter 1

      History of Hemophilia (pages 1–5)

      Caroline Cromwell and Louis M. Aledort

    2. Chapter 2

      Hemophilia Care in the Modern World (pages 6–9)

      Christine A. Lee

    3. Chapter 3

      Comprehensive Care Model in Hemophilia (pages 10–13)

      Prasad Mathew

  3. Part 2: General Topics

    1. Chapter 4

      When Should we Switch from On-Demand to Prophylaxis Regimen? (pages 15–20)

      José A. Aznar, Andrés Moret, Lydia Abad-Franch, Ana R. Cid, Saturnino Haya and Felipe Querol

    2. Chapter 5

      Prophylaxis in Children (pages 21–26)

      Marilyn J. Manco-Johnson

    3. Chapter 6

      Prophylaxis in Adults with Hemophilia (pages 27–29)

      Victor Jiménez-Yuste, Emérito-Carlos Rodríguez-Merchán, Maria-Teresa Alvarez-Román and Mónica Martín-Salces

    4. Chapter 7

      The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money? (pages 30–34)

      Alec Miners

    5. Chapter 8

      The Transition of Care for the Young Adult Hemophilia Patient (pages 35–38)

      Pia Petrini

    6. Chapter 9

      Perinatal Clinical Care and Molecular Diagnosis in Hemophilia (pages 39–43)

      Carmen Altisent and Francisco Vidal

    7. Chapter 10

      Managing the Mature Person with Hemophilia (pages 44–48)

      Savita Rangarajan and Thynn Thynn Yee

    8. Chapter 11

      Quality of Life in Hemophilia (pages 49–52)

      Eduardo Remor

  4. Part 3: Inhibitors

    1. Chapter 12

      Immunology of Inhibitor Development (pages 53–59)

      Birgit M. Reipert, Christoph J. Hofbauer, Katharina N. Steinitz, Hans-Peter Schwarz and Frank M. Horling

    2. Chapter 13

      Epidemiology of Inhibitors (pages 60–67)

      Johanna G. van der Bom

    3. Chapter 14

      Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A (pages 68–73)

      Günter Auerswald and Karin Kurnik

    4. Chapter 15

      Prediction of Inhibitors in Severe Hemophilia (pages 74–78)

      H. Marijke van den Berg and Kathelijn Fischer

    5. Chapter 16

      Genetic Basis for Inhibitor Development (pages 79–83)

      Johannes Oldenburg and Anna Pavlova

    6. Chapter 17

      Non-Genetic Risk Factors for Inhibitor Development (pages 84–88)

      Lisa N. Boggio and Mindy L. Simpson

  5. Part 4: Inhibitor Treatment

    1. Chapter 18

      Immune Tolerance Induction Programs (pages 89–96)

      Jan Blatny and Prasad Mathew

    2. Chapter 19

      Prophylaxis in Hemophilia a Patients with Inhibitors (pages 97–101)

      Leonard A. Valentino and Guy Young

    3. Chapter 20

      Treatment of Bleeding in FVIII Inhibitor Patients (pages 102–106)

      Paul L. F. Giangrande and Jerome Teitel

    4. Chapter 21

      Discordancy of Bypassing Therapy (pages 107–110)

      Jan Astermark

  6. Part 5: Joint Health and Disease

    1. Chapter 22

      Experimental Studies on Hemarthrosis, Synovitis and Arthropathy (pages 111–116)

      Leonard A. Valentino and Narine Hakobyan

    2. Chapter 23

      Assessment of Joint Involvement in Hemophilia (pages 117–120)

      Erik Berntorp

    3. Chapter 24

      Imaging of the Hemophilic Joint (pages 121–126)

      Carmen Martin-Hervás and Emérito-Carlos Rodríguez-Merchán

    4. Chapter 25

      Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: The Role of Orthopedic Surgery (pages 127–132)

      Emérito-Carlos Rodríguez-Merchán, Victor Jimenez-Yuste and Nicholas J. Goddard

    5. Chapter 26

      Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery (pages 133–137)

      Gerard Dolan, Donna M. DiMichele and Emérito-Carlos Rodríguez-Merchán

  7. Part 6: New Developments

    1. Chapter 27

      New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins (pages 139–145)

      Leonard A. Valentino

    2. Chapter 28

      Current and Future Approaches to Gene Therapy in Patients with Hemophilia (pages 146–149)

      Maria-Teresa Alvarez-Román, Monica Martín-Salces, Victor Jiménez-Yuste and Emérito-Carlos Rodríguez-Merchán

    3. Chapter 29

      New Developments in Hemophilic Arthropathy (pages 150–155)

      Emérito-Carlos Rodríguez-Merchán and Leonard A. Valentino

    4. Chapter 30

      Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm (pages 156–161)

      Nichan Zourikian and Angela L. Forsyth

    5. Chapter 31

      Laboratory Assays to Predict Response to Bypassing Agents (pages 162–166)

      Benny Sørensen and Claude Negrier

    6. Chapter 32

      Combination/Sequential Use of Bypassing Agents (pages 167–170)

      Alessandro Gringeri

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      Index (pages 171–176)

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