The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

Copyright © 2009 Blackwell Publishing Ltd

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

Editor(s): J. André Knottnerus, Frank Buntinx

Published Online: 2 FEB 2009

Print ISBN: 9781405157872

Online ISBN: 9781444300574

DOI: 10.1002/9781444300574

About this Book

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About The Product

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The Evidence Base of Clinical Diagnosis has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.


With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xiii)

    2. Chapter 1

      General Introduction: Evaluation of Diagnostic Procedures (pages 1–19)

      J. André Knottnerus, Frank Buntinx and Chris van Weel

    3. Chapter 2

      The Architecture of Diagnostic Research (pages 20–41)

      R. Brian Haynes and John J. You

    4. Chapter 3

      Assessment of the Accuracy of Diagnostic Tests: The Cross-Sectional Study (pages 42–62)

      J. André Knottnerus and Jean W. Muris

    5. Chapter 4

      Diagnostic Testing and Prognosis: The Randomized Controlled Trial in Test Evaluation Research (pages 63–82)

      Jeroen G. Lijmer and Patrick M. M. Bossuyt

    6. Chapter 5

      The Diagnostic Before–After Study to Assess Clinical Impact (pages 83–95)

      J. André Knottnerus, Geert-Jan Dinant and Onno P. van Schayck

    7. Chapter 6

      Designing Studies to Ensure that Estimates of Test Accuracy Will Travel (pages 96–117)

      Les M. Irwig, Patrick M. M. Bossuyt, Paul P. Glasziou, Constantine Gatsonis and Jeroen G. Lijmer

    8. Chapter 7

      Analysis of Data on the Accuracy of Diagnostic Tests (pages 118–145)

      J. Dik F. Habbema, René Eijkemans, Pieta Krijnen and J. André Knottnerus

    9. Chapter 8

      Multivariable Analysis in Diagnostic Accuracy Studies: What are the Possibilities? (pages 146–166)

      Frank Buntinx, Bert Aertgeerts, Marc Aerts, Rudi Bruyninckx, J. André Knottnerus, Ann van den Bruel and Jef van den Ende

    10. Chapter 9

      Standards for Reporting on Diagnostic Accuracy Studies (pages 167–179)

      Patrick M. M. Bossuyt and Nynke Smidt

    11. Chapter 10

      Guidelines for Conducting Systematic Reviews of Studies Evaluating the Accuracy of Diagnostic Tests (pages 180–212)

      Frank Buntinx, Bert Aertgeerts and Petra Macaskill

    12. Chapter 11

      Producing and Using Clinical Prediction Rules (pages 213–236)

      Tom Fahey and Johan van der Lei

    13. Chapter 12

      Clinical Problem Solving and Diagnostic Decision Making: A Selective Review of the Cognitive Research Literature (pages 237–255)

      Alan Schwartz and Arthur S. Elstein

    14. Chapter 13

      Improving Test Ordering and its Diagnostic Cost-Effectiveness in Clinical Practice—Bridging the Gap between Clinical Research and Routine Health Care (pages 256–272)

      Ron Winkens, Trudy van der Weijden, Hans Severens and Geert-Jan Dinant

    15. Chapter 14

      Epilogue: Overview of Evaluation Strategy and Challenges (pages 273–284)

      J. André Knottnerus, Ann van den Bruel and Frank Buntinx

    16. You have free access to this content
      Index (pages 285–302)

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