The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

Editor(s): J. André Knottnerus, Frank Buntinx

Published Online: 2 FEB 2009

Print ISBN: 9781405157872

Online ISBN: 9781444300574

DOI: 10.1002/9781444300574

About this Book

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The Evidence Base of Clinical Diagnosis has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.


With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

Table of contents

    1. You have free access to this content
    2. Chapter 6

      Designing Studies to Ensure that Estimates of Test Accuracy Will Travel (pages 96–117)

      Les M. Irwig, Patrick M. M. Bossuyt, Paul P. Glasziou, Constantine Gatsonis and Jeroen G. Lijmer

    3. Chapter 7

      Analysis of Data on the Accuracy of Diagnostic Tests (pages 118–145)

      J. Dik F. Habbema, René Eijkemans, Pieta Krijnen and J. André Knottnerus

    4. Chapter 8

      Multivariable Analysis in Diagnostic Accuracy Studies: What are the Possibilities? (pages 146–166)

      Frank Buntinx, Bert Aertgeerts, Marc Aerts, Rudi Bruyninckx, J. André Knottnerus, Ann van den Bruel and Jef van den Ende

    5. You have free access to this content

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