Textbook of Hemophilia, Second Edition

Copyright © 2010 Blackwell Publishing Ltd

Textbook of Hemophilia, Second Edition

Editor(s): Christine A. Lee, Erik E. Berntorp, W. Keith Hoots

Published Online: 13 AUG 2010 11:09AM EST

Print ISBN: 9781405169141

Online ISBN: 9781444318555

DOI: 10.1002/9781444318555

About this Book

Product Information

About The Product

The Textbook of Hemophilia has become a definitive resource for all those managing hemophilia patients. It covers all the common and rare bleeding disorders, both in terms of clinical management as well as the genetic, laboratory, financial and psychological aspects.

This second edition covers all the latest developments in the field of hemophilia, with new chapters on:

  • the genetic and molecular basis of inherited blood disorders
  • how to manage adolescent and older patients
  • emergency medicine and inherited blood disorders
  • national hemophilia databases

Drawing on the vast experience of the authors, the aim of this textbook remains the same - to improve the care of patients suffering from hemophilia. The book is full of detailed guidance and advice on everyday clinical questions making it invaluable to all trainee and practicing hematologists.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xii)

    1. You have free access to this content
      Color Plates (pages c1–c4)

    1. Historical Introduction (pages 1–6)

      Christine A. Lee

  4. Part I: Introduction

    1. Chapter 1

      Overview of Hemostasis (pages 7–12)

      Kathleen Brummel Ziedins and Kenneth G. Mann

    2. Chapter 2

      Cellular Processing of Factor VIII and Factor IX (pages 13–23)

      Michael U. Callaghan and Randal J. Kaufman

  5. Part II: Hemophilia A

    1. Chapter 3

      Molecular Basis of Hemophilia A (pages 24–32)

      Geoffrey Kemball-Cook and Keith Gomez

    2. Chapter 4

      Phenotypic–Genotypic Relationship (pages 33–37)

      H. Marijke van den Berg and Kathelijn Fischer

    3. Chapter 5

      Prophylaxis (pages 38–43)

      Kathelijn Fischer and H. Marijke van den Berg

    4. Chapter 6

      Continuous Infusion of Coagulation Products in Hemophilia (pages 44–51)

      Angelika Batorova and Uri Martinowitz

  6. Part III: Inhibitors to Factor VIII

    1. Chapter 7

      Inhibitors to Factor VIII—Immunology (pages 52–56)

      Jean-Marie R. Saint-Remy and Marc G. Jacquemin

    2. Chapter 8

      Genetic and Environmental Risk Factors for Inhibitor Development (pages 57–61)

      Jan Astermark

    3. Chapter 9

      Inhibitors to Factor VIII: Mild and Moderate Hemophilia (pages 62–65)

      Kathelijne Peerlinck and Marc Jacquemin

    4. Chapter 10

      Inhibitors to Factor VIII/IX: Immune Tolerance (pages 66–74)

      Donna DiMichele

    5. Chapter 11

      Inhibitors to Factor VIII: Treatment of Acute Bleeds (pages 75–80)

      Claude Negrier

  7. Part IV: Acquired Hemophilia

    1. Chapter 12

      Acquired Inhibitors to Factor VIII (pages 81–87)

      Suman L. Sood and Craig M. Kessler

  8. Part V: Hemophilia B

    1. Chapter 13

      Hemophilia B—Molecular Basis (pages 88–93)

      Keith Gomez

    2. Chapter 14

      Factor IX Inhibitors in Hemophilia B (pages 94–96)

      Jeanne M. Lusher and Meera Chitlur

    3. Chapter 15

      Treatment of Inhibitors in Hemophilia B (pages 97–103)

      Anand Tandra and Amy D. Shapiro

  9. Part VI: Pharmacokinetics of Factors VIII & IX

    1. Chapter 16

      Pharmacokinetics (pages 104–110)

      Sven Björkman and Erik E. Berntorp

  10. Part VII: Hemophilia—Birth to Old Age

    1. Chapter 17

      The Neonate with Hemophilia (pages 111–117)

      Angela E. Thomas and Elizabeth Chalmers

    2. Chapter 18

      Work-up of a Bleeding Child (pages 118–126)

      Manuel D. Carcao and Victor S. Blanchette

    3. Chapter 19

      Care of the Child with Hemophilia (pages 127–132)

      Rolf Ljung

    4. Chapter 20

      Adolescence (pages 133–137)

      Martti A. Siimes

    5. Chapter 21

      Hemophilia and Medicine in Old Age (pages 138–145)

      Eveline P. Mauser-Bunschoten and Roger E. G. Schutgens

  11. Part VIII: Products used to Treat Hemophilia

    1. Chapter 22

      Products used to Treat Hemophilia: Recombinant Products (pages 146–152)

      Akira Yoshioka

    2. Chapter 23

      Plasma-Derived Coagulation Factor Concentrates (pages 153–158)

      Paul L. F. Giangrande

    3. Chapter 24

      Products used to Treat Hemophilia: Recombinant Factor VIIa (pages 159–164)

      Ulla Hedner

    4. Chapter 25

      Products used to Treat Hemophilia: Dosing (pages 165–169)

      Miguel A. Escobar

    5. Chapter 26

      Products used to Treat Hemophilia: Regulation (pages 170–175)

      Albert Farrugia

  12. Part IX: Musculoskeletal

    1. Chapter 27

      Joint Replacement (pages 176–181)

      Nicholas Goddard

    2. Chapter 28

      Synoviorthesis in Hemophilia (pages 182–186)

      E. Carlos Rodriguez-Merchan

    3. Chapter 29

      Pseudotumors in Patients with Hemophilia (pages 187–190)

      Michael Heim and Uri Martinowitz

    4. Chapter 30

      Imaging Modalities for Assessment of Hemophilic Arthropathy (pages 191–199)

      Andrea S. Doria and Björn Lundin

    5. Chapter 31

      Physiotherapy in the Management of Hemophilia (pages 200–206)

      Karen Beeton and Jane Padkin

    6. Chapter 32

      Clinimetric Instruments in Hemophilia (pages 207–214)

      Pradeep M. Poonnoose and Frank R. van Genderen

  13. Part X: Transfusion-Transmitted Disease

    1. Chapter 33

      Hepatitis and Hemophilia (pages 215–221)

      Michael Makris and Geoffrey Dusheiko

    2. Chapter 34

      Transfusion-Transmitted Disease: Emerging Infections (pages 222–225)

      Thomas R. Kreil

  14. Part XI: Gene Therapy

    1. Chapter 35

      Hemophilia Gene Therapy: An Overview (pages 226–230)

      David Lillicrap

    2. Chapter 36

      Gene Therapy Trials in Hemophilia A and B (pages 231–238)

      Katherine A. High and J. Fraser Wright

    3. Chapter 37

      Gene Therapy: Molecular Engineering of Factor VIII and Factor IX (pages 239–246)

      Steven W. Pipe

  15. Part XII: Laboratory

    1. Chapter 38

      Laboratory Assays in Hemophilia (pages 247–253)

      Jørgen Ingerslev

    2. Chapter 39

      Standardization of Assays in Hemophilia (pages 254–262)

      Sanj Raut and Trevor W. Barrowcliffe

    3. Chapter 40

      Global Laboratory Assays in Hemophilia (pages 263–268)

      Benny Sørensen and Guy Young

  16. Part XIII: Obstetrics & Gynaecology

    1. Chapter 41

      Obstetrics and Gynecology: Hemophilia (pages 269–277)

      Rezan A. Kadir and Christine A. Lee

  17. Part XIV: von Willebrand Disease

    1. Chapter 42

      von Willebrand Disease: Molecular Aspects (pages 278–285)

      Anne Goodeve

    2. Chapter 43

      von Willebrand Disease: Epidemiology (pages 286–293)

      Francesco Rodeghiero and Giancarlo Castaman

    3. Chapter 44

      von Willebrand Disease: Biologic Diagnosis (pages 294–301)

      Veronica H. Flood and Robert R. Montgomery

    4. Chapter 45

      Classification and Clinical Aspects of Von Willebrand Disease (pages 302–308)

      Augusto B. Federici

  18. Part XV: Treatment of Von Willebrand Disease

    1. Chapter 46

      Women and Von Willebrand Disease (pages 309–315)

      Peter A. Kouides

    2. Chapter 47

      Treatment of Von Willebrand Disease: Desmopressin (pages 316–319)

      Pier M. Mannucci

    3. Chapter 48

      Treatment of Von Willebrand Disease: Therapeutic Concentrates (pages 320–327)

      Peter W. Collins

  19. Part XVI: Rare Bleeding Disorders

    1. Chapter 49

      Factor II (pages 328–331)

      Jan Astermark

    2. Chapter 50

      Factor V and Combined Factor V and VIII Deficiencies (pages 332–340)

      Flora Peyvandi and Marta Spreafico

    3. Chapter 51

      Congenital Factor VII Deficiency (pages 341–347)

      Guglielmo Mariani and Alberto Dolce

    4. Chapter 52

      Factor X and Factor X Deficiency (pages 348–354)

      David J. Perry

    5. Chapter 53

      Factor XI Deficiency (pages 355–361)

      Uri Seligsohn and Paula H. B. Bolton-Maggs

    6. Chapter 54

      Factor XIII Deficiency (pages 362–368)

      Diane Nugent and Loan Hsieh

    7. Chapter 55

      Fibrinogen (pages 369–375)

      Michael Laffan

    8. Chapter 56

      Miscellaneous Bleeding Disorders (pages 376–393)

      Anjali A. Sharathkumar and Amy D. Shapiro

  20. Part XVII: Emergency Medicine

    1. Chapter 57

      Emergency Management of Hemophilia (pages 394–400)

      W. Keith Hoots

  21. Part XVIII: Quality of Life

    1. Chapter 58

      Quality of Life in Hemophilia (pages 401–408)

      Sylvia von Mackensen and Alessandro Gringeri

  22. Part XIX: Economics

    1. Chapter 59

      The Economics of Hemophilia Treatment (pages 409–414)

      Katarina Steen Carlsson and Erik Berntorp

  23. Part XX: Comprehensive Care and Delivery of Care

    1. Chapter 60

      National Hemophilia Databases (pages 415–419)

      Charles R. M. Hay

    2. Chapter 61

      Comprehensive Care and Delivery of Care: The Developed World (pages 420–428)

      Christopher A. Ludlam

    3. Chapter 62

      Comprehensive Care and Delivery of Care in Hemophilia: The Developing World (pages 429–434)

      Alok Srivastava and Auro Viswabandya

    4. Chapter 63

      Comprehensive Care and Delivery of Care: The Global Perspective (pages 435–442)

      Bruce L. Evatt and Alison Street

    1. You have free access to this content
      Index (pages 443–464)

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