Genetic and Molecular Aspects of Sport Performance

Copyright © 2011 Blackwell Publishing Ltd

Genetic and Molecular Aspects of Sport Performance

Editor(s): Claude Bouchard, Eric P. Hoffman

Published Online: 25 NOV 2010 10:09AM EST

Print ISBN: 9781444334456

Online ISBN: 9781444327335

DOI: 10.1002/9781444327335

About this Book

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About The Product

This is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance.

The initial chapters address the basic science of genomics and genetics and the regulation of gene expression.  Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons.  A final section addresses the issue of the contribution of specific genes and molecular markers as related to endurance, strength and power, and responsiveness to specific conditioning programs. 

This latest volume in the Encyclopaedia of Sports Medicine Series from the Medical Commission of the International Olympic Committee is a must for sports and exercise scientists who require a thorough guide to the most cutting edge science in this expanding field.

Table of contents

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      Front Matter (pages i–xiv)

  2. Part 1: The Science of Genomics and Genetics

    1. Chapter 1

      The Human Genome and Epigenome (pages 1–13)

      John J. Mulvihill, Klaas J. Wierenga and Chad M. Kerksick

    2. Chapter 2

      Mitochondrial Medicine in Health and Disease: Interface Between Athletic Performance and Therapeutics (pages 14–32)

      Douglas C. Wallace

    3. Chapter 3

      Characterizing the Extent of Human Genetic Variation for Performance-Related Traits (pages 33–45)

      John Blangero and Jack W. Kent

    4. Chapter 4

      Current Proteome Profiling Methods (pages 46–57)

      Yetrib Hathout, Catherine A. Formolo, Kristy J. Brown and Javad Nazarian

    5. Chapter 5

      Bioinformatics and Public Access Resources (pages 58–69)

      Yue Wang, Huai Li, David J. Miller and Jianhua Xuan

    6. Chapter 6

      Search for Genes Influencing Complex Traits (pages 70–78)

      Corneliu Henegar, Henri Hooton and Karine Clément

  3. Part 2: Evidence from Genetic Epidemiology Studies

    1. Chapter 7

      Genetic Epidemiology, Physical Activity, and Inactivity (pages 79–89)

      Molly S. Bray, Janet E. Fulton, Nishan Sudheera Kalupahana and J. Timothy Lightfoot

    2. Chapter 8

      Role of Genetics Factors in Sport Performance: Evidence from Family Studies (pages 90–100)

      Louis Pérusse

    3. Chapter 9

      Twin Studies in Sport Performance (pages 101–109)

      Gaston P. Beunen, Maarten W. Peeters and Robert M. Malina

    4. Chapter 10

      Twin and Family Studies of Training Responses (pages 110–120)

      Mark A. Sarzynski, Tuomo Rankinen and Claude Bouchard

    5. Chapter 11

      Ethnic Differences in Sport Performance (pages 121–132)

      Yannis P. Pitsiladis

    6. Chapter 12

      Selection Experiments in Rodents to Define the Complexity and Diversity of Endurance Capacity (pages 133–147)

      Steven L. Britton and Lauren Gerard Koch

  4. Part 3: Contributions of Specific Genes and Markers

    1. Chapter 13

      Genes and Endurance Performance (pages 149–158)

      Bernd Wolfarth

    2. Chapter 14

      Genes and Strength and Power Phenotypes (pages 159–176)

      Martine A. I. Thomis

    3. Chapter 15

      Genes and Response to Training (pages 177–184)

      Tuomo Rankinen, Mark A. Sarzynski and Claude Bouchard

    4. Chapter 16

      Genetic Determinants of Exercise Performance: Evidence from Transgenic and Null Mouse Models (pages 185–194)

      Eunhee Chung and Leslie A. Leinwand

    5. Chapter 17

      The ACE Gene and Performance (pages 195–203)

      James R. A. Skipworth, Zudin A. Puthucheary, Jai Rawal and Hugh E. Montgomery

    6. Chapter 18

      The ACTN3 Gene and Human Performance (pages 204–214)

      Daniel G. Macarthur and Kathryn N. North

    7. Chapter 19

      Mitochondrial DNA Sequence Variation and Performance (pages 215–226)

      Shinya Kuno, Hirofumi Zempo and Haruka Murakami

    8. Chapter 20

      Genes, Exercise, and Lipid Metabolism (pages 227–239)

      Yohan Bossé

    9. Chapter 21

      Genes, Exercise, and Glucose and Insulin Metabolism (pages 240–248)

      Leonidas G. Karagounis and John A. Hawley

    10. Chapter 22

      Genes, Exercise, and Cardiovascular Phenotypes (pages 249–261)

      James M. Hagberg

    11. Chapter 23

      Genes, Exercise, and Protein Metabolism (pages 262–282)

      Mark A. Tarnopolsky

    12. Chapter 24

      The Regulation of Physical Activity by Genetic Mechanisms: Is there a Drive to be Active? (pages 283–293)

      Nishan Sudheera Kalupahana, Naima Moustaid-Moussa, Jung Han Kim, Brynn H. Voy, David Bassett, Molly S. Bray and J. Timothy Lightfoot

    13. Chapter 25

      Genes, Exercise, and Psychological Factors (pages 294–305)

      Eco J. C. De Geus and Marleen H. M. De Moor

  5. Part 4: Systems Biology of Exercise and Training

    1. Chapter 26

      A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism (pages 307–318)

      James A. Timmons and Jorn W. Helge

    2. Chapter 27

      Systems Biology Through Time Series Data—A Strength of Muscle Remodeling (pages 319–329)

      Monica Hubal, Zuyi Wang and Eric P. Hoffman

    3. Chapter 28

      Proteomics in Exercise Training Research (pages 330–342)

      Dustin S. Hittel

    4. Chapter 29

      The Influence of Physical Exercise on Adult Stem Cells (pages 343–349)

      Fawzi Kadi

  6. Part 5: Ethical and Societal Implications

    1. Chapter 30

      Genetics and Ethics in Elite Sport (pages 351–361)

      Sigmund Loland

    2. Chapter 31

      Genes and Talent Selection (pages 362–372)

      Stephen M. Roth

    3. Chapter 32

      Performance Enhancement by Gene Doping (pages 373–382)

      Anna Baoutina

    4. Chapter 33

      Bioethical Concerns in a Culture of Human Enhancement (pages 383–392)

      Andy Miah

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      Index (pages 393–404)

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