Von Willebrand Disease: Basic and Clinical Aspects

Von Willebrand Disease: Basic and Clinical Aspects

Editor(s): Augusto B. Federici, Christine A. Lee, Erik E. Berntorp, David Lillicrap, Robert R. Montgomery

Published Online: 21 MAR 2011

Print ISBN: 9781405195126

Online ISBN: 9781444329926

DOI: 10.1002/9781444329926

About this Book

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease.

This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding.

Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy.

Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Table of contents

    1. You have free access to this content
    2. Chapter 5

      Animal Models in von Willebrand Disease (pages 63–73)

      Cécile V. Denis, Olivier D. Christophe and Peter J. Lenting

    3. Chapter 6

      Classification of von Willebrand Disease (pages 74–85)

      Javier Batlle, Almudena Pérez-Rodríguez and María Fernanda López-Fernández

    4. Chapter 20

      Gene Therapy for Von Willebrand Disease (pages 231–244)

      Marinee K. L. Chuah, Inge Petrus and Thierry VandenDriessche

    5. You have free access to this content

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