Inflammation and Allergy Drug Design

Copyright © 2011 Blackwell Publishing Ltd

Inflammation and Allergy Drug Design

Editor(s): Kenji Izuhara, Stephen T. Holgate, Marsha Wills-Karp

Published Online: 27 JUL 2011

Print ISBN: 9781444330144

Online ISBN: 9781444346688

DOI: 10.1002/9781444346688

About this Book

Product Information

About The Product

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.

Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.

This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate
students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xiii)

    1. Chapter 1

      Novel Anti-Inflammatory Drugs Based on Targeting Lung Dendritic Cells and Airway Epithelial Cells (pages 1–14)

      Bart N. Lambrecht, Maud Plantinga, Monique Willart and Hamida Hammad

    1. Chapter 2

      Role of Th2 Cells in the Allergic Diathesis (pages 15–25)

      Marsha Wills-karp

  4. Part I: Cells Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 3

      Importance of Th17- and Th1-Associated Responses for the Development of Asthma (pages 27–38)

      Tomohiro Yoshimoto, Hiroko Tsutsui and Kenji Nakanishi

    2. Chapter 4

      Regulatory T Cells (pages 39–57)

      Chris Corrigan and Kimuli Ryanna

    3. Chapter 5

      A Role for Natural Killer T-Cell Subsets in the Pathogenesis of Various Allergic Disorders (pages 59–66)

      Hiroshi Watarai, Michishige Harada, Mayumi Tamari and Masaru Taniguchi

    4. Chapter 6

      Regulatory Roles of B Cells in Allergy and Inflammation (pages 67–77)

      Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai

    5. Chapter 7

      Mast Cells (pages 79–105)

      Mindy Tsai and Stephen J. Galli

    6. Chapter 8

      Eosinophils (pages 107–121)

      Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen and Sergei I. Ochkur

    7. Chapter 9

      Basophils in Inflammation and Allergy Drug Design (pages 123–137)

      Donald MacGlashan

    8. Chapter 10

      Epithelial Cells (pages 139–148)

      Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz and Darryl Knight

    9. Chapter 11

      Fibroblasts (pages 149–162)

      Alastair G. Stewart, Lilian Soon and Michael Schuliga

    10. Chapter 12

      Airway Smooth Muscle Cells (pages 163–171)

      Andrew J. Halayko and Pawan Sharma

  5. Part II: Cytokines Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 13

      Interleukin 4, Interleukin 13, and Interleukin 9 (pages 173–185)

      Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi and Shoichi Suzuki

    2. Chapter 14

      Interleukin 3, Interleukin 5, and Granulocyte–Macrophage Colony-Stimulating Factor (pages 187–196)

      Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh and Manel Jordana

    3. Chapter 15

      Interleukin 15, Interleukin 17, and Interleukin 25 (pages 197–204)

      Hiroshi Nakajima and Itsuo Iwamoto

    4. Chapter 16

      Thymic Stromal Lymphopoietin (pages 205–214)

      Kazuhiko Arima and Yong-Jun Liu

    5. Chapter 17

      Interleukin 10 (pages 215–224)

      Whitney W. Stevens, Larry Borish and John W. Steinke

    6. Chapter 18

      Tumor Necrosis Factor Alpha (pages 225–235)

      Christopher Brightling, Latifa Chachi, Dhan Desai and Yassine Amrani

    7. Chapter 19

      Profibrotic and Angiogenic Factors in Asthma (pages 237–252)

      Neville Berkman and Francesca Levi-Schaffer

    8. Chapter 20

      Chemokines (pages 253–261)

      Luis M. Teran and Juan R. Velazquez

    9. Chapter 21

      Epithelial Growth Factors (pages 263–270)

      Yasuhiro Gon and Shu Hashimoto

  6. Part III: Other Mediators Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 22

      Prostanoids (pages 271–283)

      Sarah A. Maher, Deborah L. Clarke and Maria G. Belvisi

    2. Chapter 23

      Leukotrienes (pages 285–295)

      Katsuhide Okunishi and Marc Peters-Golden

    3. Chapter 24

      Proteases in Allergy (pages 297–305)

      Keisuke Oboki and Hirohisa Saito

    4. Chapter 25

      Toll-Like Receptors (pages 307–316)

      Jessica L. Allen, Aurelien Trompette and Christopher L. Karp

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      Index (pages 317–330)

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