Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

Editor(s): Kenji Izuhara, Stephen T. Holgate, Marsha Wills-Karp

Published Online: 27 JUL 2011

Print ISBN: 9781444330144

Online ISBN: 9781444346688

DOI: 10.1002/9781444346688

About this Book

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.

Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.

This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate
students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

Table of contents

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  1. Part I: Cells Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 8

      Eosinophils (pages 107–121)

      Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen and Sergei I. Ochkur

    2. Chapter 10

      Epithelial Cells (pages 139–148)

      Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz and Darryl Knight

    3. Chapter 11

      Fibroblasts (pages 149–162)

      Alastair G. Stewart, Lilian Soon and Michael Schuliga

  2. Part II: Cytokines Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 13

      Interleukin 4, Interleukin 13, and Interleukin 9 (pages 173–185)

      Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi and Shoichi Suzuki

    2. Chapter 17

      Interleukin 10 (pages 215–224)

      Whitney W. Stevens, Larry Borish and John W. Steinke

    3. Chapter 18

      Tumor Necrosis Factor Alpha (pages 225–235)

      Christopher Brightling, Latifa Chachi, Dhan Desai and Yassine Amrani

  3. Part III: Other Mediators Contributing to the Pathogenesis of Allergic Diseases in the Respiratory Tract

    1. Chapter 22

      Prostanoids (pages 271–283)

      Sarah A. Maher, Deborah L. Clarke and Maria G. Belvisi

    2. Chapter 23

      Leukotrienes (pages 285–295)

      Katsuhide Okunishi and Marc Peters-Golden

    3. Chapter 25

      Toll-Like Receptors (pages 307–316)

      Jessica L. Allen, Aurelien Trompette and Christopher L. Karp

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