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Immunotherapy in Transplantation: Principles and Practice

Copyright © 2012 Blackwell Publishing Ltd.

Immunotherapy in Transplantation: Principles and Practice

Editor(s): Bruce Kaplan, Gilbert J. Burckart, Fadi G. Lakkis

Published Online: 19 APR 2012 05:50AM EST

Print ISBN: 9781405182713

Online ISBN: 9781444355628

DOI: 10.1002/9781444355628

About this Book

Product Information

About The Product

This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–xi)

    1. You have free access to this content
      Supplemental Images (pages c1–c12)

  3. Part 1: Transplantation Immunobiology

    1. Chapter 1

      The Immune Response to a Transplanted Organ: An Overview (pages 3–9)

      Fadi G. Lakkis

    2. Chapter 2

      Antigen Presentation in Transplantation (pages 10–18)

      Martin H. Oberbarnscheidt and Fadi G. Lakkis

    3. Chapter 3

      The T Cell Response to Transplantation Antigens (pages 19–37)

      Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh and Peter S. Heeger

    4. Chapter 4

      The B Cell Response to Transplantation Antigens (pages 38–53)

      Roger Sciammas, Anita S. Chong and Robert B. Colvin

    5. Chapter 5

      The Innate Response to a Transplanted Organ (pages 54–61)

      Daniel R. Goldstein and Laurence A. Turka

    6. Chapter 6

      Regulation of the Alloimmune Response (pages 62–78)

      Kathryn J. Wood and Terry B. Strom

  4. Part 2: Transplantation Clinical Pharmacology

    1. Chapter 7

      Pharmacokinetics (pages 81–94)

      Venkateswaran C. Pillai and Raman Venkataramanan

    2. Chapter 8

      Therapeutic Drug Monitoring for Immunosuppressive Agents (pages 95–113)

      Michael C. Milone and Leslie M. J. Shaw

    3. Chapter 9

      Pharmacometrics: Concepts and Applications to Drug Development (pages 114–132)

      Mallika Lala and Jogarao V. S. Gobburu

    4. Chapter 10

      Pharmacogenomics and Organ Transplantation (pages 133–145)

      Gilbert J. Burckart and Richard M. Watanabe

    5. Chapter 11

      Study Design/Process of Development: Clinical Studies (pages 146–159)

      Richard D. Mamelok

  5. Part 3: Agents

    1. Chapter 12

      Corticosteroids (pages 163–170)

      Olivia R. Blume, Sarah E. Yost and Bruce Kaplan

    2. Chapter 13

      Azathioprine (pages 171–181)

      Barry J. Browne

    3. Chapter 14

      Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate (pages 182–196)

      David Hager, Arjang Djamali and Bruce Kaplan

    4. Chapter 15

      Cyclosporine: Molecular Action to Clinical Therapeutics (pages 197–223)

      Bradford Strijack and Paul A. Keown

    5. Chapter 16

      Tacrolimus (pages 224–240)

      William E. Fitzsimmons

    6. Chapter 17

      Inhibitors of Mammalian Target of Rapamycin (pages 241–272)

      Barry D. Kahan

    7. Chapter 18

      Inhibitors Targeting JAK3 (pages 273–289)

      Gary Chan and Paul S. Changelian

    8. Chapter 19

      Cyclophosphamide (pages 290–295)

      John J. Curtis

    9. Chapter 20

      Application of Antisense Technology in Medicine (pages 296–315)

      Beata Mierzejewska and Stanislaw M. Stepkowski

    10. Chapter 21

      The Role of Ganciclovir in Transplantation (pages 316–329)

      Lyndsey J. Bowman and Daniel C. Brennan

    11. Chapter 22

      Transplantation Immunotherapy with Antithymocyte Globulin (ATG) (pages 330–345)

      John L. Dzuris, Christian Bloy, Melanie Ruzek and John M. Williams

    12. Chapter 23

      The Role of Alemtuzumab in Solid Organ Transplantation (pages 346–361)

      Avinash Agarwal, David Bruno and Stuart J. Knechtle

    13. Chapter 24

      Rituximab, an Anti-CD20 Monoclonal Antibody (pages 362–377)

      Mark D. Pescovitz

    14. Chapter 25

      The Anti-Interleukin 2 Receptor Antibodies (pages 378–384)

      Muna Alnimri and Flavio Vincenti

    15. Chapter 26

      Infliximab/Anti-TNF (pages 385–398)

      Marina Vardanyan, Edward C. Parkin and Horacio L. Rodriguez Rilo

    16. Chapter 27

      CTLA4-Ig (pages 399–406)

      Sarah E. Yost and Bruce Kaplan

    17. Chapter 28

      Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade (pages 407–428)

      Swetha K. Srinivasan, Helen L. Triemer and Allan D. Kirk

    18. Chapter 29

      Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation (pages 429–445)

      Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng and Ashley A. Vo

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      Index (pages 447–459)

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