Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

Editor(s): Klaus T. Wanner, Georg Höfner

Published Online: 24 MAY 2007

Print ISBN: 9783527314560

Online ISBN: 9783527610907

DOI: 10.1002/9783527610907

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory.
Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Table of contents

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  1. Part I: Introduction to MS in bioanalysis

  2. Part II: Studying target-ligand interactions analyzing the ligand by MS

  3. Part III: Studying target-ligand interactions analyzing intact target-ligand complexes by MS

  4. Part IV: Studying target-ligand interactions analyzing the target binding site by MS

  5. Part V: MS in early pharmacokinetics

    1. You have free access to this content
    1. You have free access to this content

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