Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery
Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Klaus T. Wanner, Georg Höfner
Published Online: 24 MAY 2007
Print ISBN: 9783527314560
Online ISBN: 9783527610907
Book Series: Methods and Principles in Medicinal Chemistry
Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
About this Book
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory.
Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.