Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Editor(s): Rolf Dermietzel, David C. Spray, Maiken Nedergaard

Published Online: 31 MAY 2007

Print ISBN: 9783527310883

Online ISBN: 9783527611225

DOI: 10.1002/9783527611225

About this Book

This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain.
Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.

Table of contents

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  1. Part I: Ontogeny of the Blood-Brain Barrier

    1. Chapter 2

      Brain Angiogenesis and Barriergenesis (pages 41–59)

      Jeong Ae Park, Yoon Kyung Choi, Sae-Won Lee and Kyu-Won Kim

  2. Part II: The Cells of the Blood-Brain Interface

    1. Chapter 7

      The Microglial Component (pages 167–188)

      Ingo Bechmann, Angelika Rappert, Josef Priller and Robert Nitsch

    2. Chapter 9

      Responsive Astrocytic Endfeet: The Role of AQP4 in BBB Development and Functioning (pages 209–236)

      Grazia P. Nicchia, Beatrice Nico, Laura M. A. Camassa, Maria G. Mola, Domenico Ribatti, David C. Spray, Alejandra Bosco, Maria Svelto and Antonio Frigeri

  3. Part III: Hormonal and Enzymatic Control of Brain Vessels

  4. Part IV: Culturing the Blood-Brain Barrier

    1. Chapter 15

      Modeling the Blood-Brain Barrier (pages 335–355)

      Roméo Cecchelli, Caroline Coisne, Lucie Dehouck, Florence Miller, Marie-Pierre Dehouck, Valérie Buée-Scherrer and Bénédicte Dehouck

    2. Chapter 17

      Artificial Blood-Brain Barriers (pages 375–401)

      Luca Cucullo, Emily Oby, Kerri Hallene, Barbara Aumayr, Ed Rapp and Damir Janigro

  5. Part V: Drug Delivery to the Brain

    1. Chapter 19

      The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoprotein (pages 429–461)

      Sandra Turcotte, Michel Demeule, Anthony Régina, Chantal Fournier, Julie Jodoin, Albert Moghrabi and Richard Béliveau

  6. Part VI: Vascular Perfusion

  7. Part VII: Disease-Related Response

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