Vitamin B12 and B12-Proteins

Vitamin B12 and B12‐Proteins

Editor(s): B. Kräutler, D. Arigoni, B. T. Golding

Published Online: 21 DEC 2007

Print ISBN: 9783527294800

Online ISBN: 9783527612192

DOI: 10.1002/9783527612192

About this Book

This timely and topical book reviews the important developments in the 'B12-field' with regard to biological, chemical, pharmaceutical and medicinal aspects.
In over 30 chapters the approx. 100 internationally renowned authors give deeper insight into the prospering research activites around B12. This book is a must for everybody who works with or on vitamins and porphyrine (-like) ring systems.
Topics of particular interest include: Biosynthesis of Vitamin B12; B12-catalyzed enzymatic reactions and their mechanisms; structural B12-chemistry; reactivity of B12 and B12-models; structure and function of B12-proteins; metabolic transport and storage of B12; pathological effects of B12-deficiency.

Table of contents

    1. You have free access to this content
  1. Part 1: B12: An Overview

  2. Part 2: B12: Biosynthesis

    1. Chapter 3

      Vitamin B12 Biosynthesis in Pseudomonas denitrificans (pages 63–79)

      Denis Thibaut, Francis Blanche, Beatrice Cameron, Joël Crouzet, Laurent Debussche, Eliabeth Rémy and Marc Vuilhorgne

  3. Part 3: B12-Proteins: Enzymatic Methyltransfer

    1. Chapter 7

      Cobalamin-Dependent Methionine Synthase from Escherichia coli: Structure and Reactivity (pages 133–155)

      C. L. Drennan, M. M. Dixon, D. M. Hoover, J. T. Jarrett, C. W. Goulding, R. G. Matthews and M. L. Ludwig

    2. Chapter 9

      Discovery of a Biological Organometallic Reaction Sequence Involving Vitamin B12 (pages 167–177)

      Stephen W. Ragsdale, Manoj Kumar, Shaying Zhao, Saurabh Menon, Javier Seravalli and Tzanko Doukov

  4. Part 4: B12-Proteins: Enzymatic Rearrangements

    1. Chapter 12

      A Mechanistic Overview of B12-dependent Processes (pages 201–216)

      Bernard T. Gelding, Rosalind J. Anderson, Susan Ashwell, Christopher H. Edwards, Ian Garnett, Friedrich Kroll and Wolfgang Buckel

    2. Chapter 15

      Mechanisms of Coenzyme B12-Dependent Carbon-Carbon and Carbon-Oxygen Rearrangements (pages 237–251)

      Harald Bothe, Gerd Bröker, Uta Müller, Iris Schall, Susanne Textor, Bernhard T. Golding and Wolfgang Buckel

    3. Chapter 16

      Glutamate Mutase (pages 253–271)

      E. Neil G. Marsh, Daniel E. Holloway and Hao-Ping Chen

    4. Chapter 19

      Model Studies for the Methylmalonyl-Succinyl Rearrangement (pages 289–301)

      Reinhart Keese, Tamis Darbre, Urs v. Am, Susanna Miiller, A. Wolleb-Gygi, Daniel Hirschi, Vuk Siljegovic, Michael Hammatter, Andris Amolins and Thomas Otten

  5. Part 5: B12:Structure and Reactivity

  6. Part 6: Without B12 and with B12?

    1. Chapter 28

      The Role of S-Adenosylmethionine as a Poor Man's Adenosylcobalamin in the Reaction of Lysine 2,3-Aminomutase (pages 436–446)

      P. A. Frey, G.H. Reed, M. L. Moss, R. M. Petrovich, M. D. Ballinger, K. W. Lieder, W. Wu, C. H. Chang, V. Bandarian, F. J. Ruzicka, R. LoBrutto and H. Beinert

  7. Part 7: B12: Medical Aspects

  8. Part 8: Appendix

    1. You have free access to this content
    1. You have free access to this content