Plasmids for Therapy and Vaccination

Plasmids for Therapy and Vaccination

Editor(s): M. Schleef

Published Online: 11 DEC 2007

Print ISBN: 9783527302697

Online ISBN: 9783527612833

DOI: 10.1002/9783527612833

About this Book

This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.

Table of contents

    1. You have free access to this content
    2. Chapter 4

      A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Porcine Femoral Arteries (pages 75–86)

      Manfred Rüdiger, Andreas Muhs, Jens Schletter, Angela Heischmann, Andreas Herrmann, Julia Dörge, Jürgen Schrader and Heiko E. Von Der Leyen

    3. Chapter 7

      Polyvalent Vectors for Coexpression of Multiple Genes (pages 119–137)

      Peter P. Müller, André Oumard, Dagmar Wirth, Andrea Kröger and Hansjörg Hauser

    4. Chapter 8

      Form Follows Function: The Design of Minimalistic Immunogenically Defined Gene Expression (MIDGE®) Constructs (pages 139–146)

      Claas Junghans, Matthias Schroff, Sven A. Koenig-Merediz, Jens Alfken, Colin Smith, Florian Sack, Reinhold Schirmbeck and Burghardt Wittig

    5. Chapter 11

      Plasmid Manufacturing – An Overview (pages 193–236)

      Guilherme N. M. Ferreira, Duarte M. F. Prazeres, Joaquim M. S. Cabral and Martin Schleef

    6. You have free access to this content