Protein Degradation Series: 4 Volume Set

Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Protein Degradation Series: 4 Volume Set

Editor(s): R. John Mayer, Aaron J. Ciechanover, Martin Rechsteiner

Published Online: 14 DEC 2007

Print ISBN: 9783527318780

Online ISBN: 9783527619320

DOI: 10.1002/9783527619320

About this Book

Product Information

About The Product

This series of four topical volumes includes more than 50 contributions covering all aspects of the molecular biology and physiology of controlled protein breakdown in higher organisms via the ubiquitin-proteasome pathway. The editors and authors comprise virtually all the top scientists in the field, including the pioneers of protein degradation research and the 2004 Nobel laureate in chemistry.
Each volume highlights a different aspect of the field, namely ubiquitin and the chemistry of life, as well as the cell biology and pathology of the ubiquitin-proteasome system, with the individual volumes featuring their own separate indices. Together, all four volumes provide the most comprehensive reference on protein degradation available.

Table of contents

  1. Part I: Ubiquitin and the Chemistry of Life

    1. You have free access to this content
      Front Matter (pages i–xvi)

    2. Chapter 1

      Brief History of Protein Degradation and the Ubiquitin System (pages 1–9)

      Avram Hershko

    3. Chapter 2

      N-terminal Ubiquitination: No Longer Such a Rare Modification (pages 10–20)

      Prof. Dr. Aaron Ciechanover

    4. Chapter 3

      Evolutionary Origin of the Activation Step During Ubiquitin-dependent Protein Degradation (pages 21–43)

      Hermann Schindelin

    5. Chapter 4

      RING Fingers and Relatives: Determinators of Protein Fate (pages 44–101)

      Kevin L. Lorick, Yien-Che Tsai, Yili Yang and Allan M. Weissman

    6. Chapter 5

      Ubiquitin-conjugating Enzymes (pages 102–134)

      Michael J. Eddins and Cecile M. Pickart

    7. Chapter 6

      The SCF Ubiquitin E3 Ligase (pages 135–155)

      Leigh Ann Higa and Hui Zhang

    8. Chapter 7

      The Structural Biology of Ubiquitin–Protein Ligases (pages 156–189)

      Ning Zheng and Nikola P. Pavletich

    9. Chapter 8

      The Deubiquitinating Enzymes (pages 190–219)

      Nathaniel S. Russell and Keith D. Wilkinson

    10. Chapter 9

      The 26S Proteasome (pages 220–247)

      Prof. Dr. Martin Rechsteiner

    11. Chapter 10

      Molecular Machines for Protein Degradation (pages 248–287)

      Matthias Bochtler, Michael Groll, Hans Brandstetter, Tim Clausen and Robert Huber

    12. Chapter 11

      Proteasome Regulator, PA700 (19S Regulatory Particle) (pages 288–316)

      George N. DeMartino and Cezary Wojcik

    13. Chapter 12

      Bioinformatics of Ubiquitin Domains and Their Binding Partners (pages 318–347)

      Kay Hofmann

    14. Chapter 13

      The COP9 Signalosome: Its Possible Role in the Ubiquitin System (pages 348–369)

      Dawadschargal Bech-Otschir, Barbara Kapelari and Wolfgang Dubiel

    15. You have free access to this content
      Subject Index (pages 370–377)

  2. Part II: The Ubiquitin–Proteasome System

    1. You have free access to this content
      Front Matter (pages I–XIV)

    2. Chapter 1

      Molecular Chaperones and the Ubiquitin–Proteasome System (pages 1–30)

      Cam Patterson and Jörg Höhfeld

    3. Chapter 2

      Molecular Dissection of Autophagy in the Yeast Saccharomyces cerevisiae (pages 31–50)

      Yoshinori Ohsumi

    4. Chapter 3

      Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes (pages 51–78)

      Huib Ovaa, Herman S. Overkleeft, Benedikt M. Kessler and Hidde L. Ploegh

    5. Chapter 4

      MEKK1: Dual Function as a Protein Kinase and a Ubiquitin Protein Ligase (pages 79–87)

      Zhimin Lu and Tony Hunter

    6. Chapter 5

      Proteasome Activators (pages 89–110)

      Andreas Förster and Christopher P. Hill

    7. Chapter 6

      The Proteasome Portal and Regulation of Proteolysis (pages 111–127)

      Monika Bajorek and Michael H. Glickman

    8. Chapter 7

      Ubiquity and Diversity of the Proteasome System (pages 129–156)

      Keiji Tanaka, Hideki Yashiroda and Shigeo Murata

    9. Chapter 8

      Proteasome-Interacting Proteins (pages 157–182)

      Jean E. O'Donoghue and Colin Gordon

    10. Chapter 9

      Structural Studies of Large, Self-Compartmentalizing Proteases (pages 183–213)

      Beate Rockel, Jürgen Bosch and Wolfgang Baumeister

    11. Chapter 10

      What the Archaeal PAN–Proteasome Complex and Bacterial ATP-Dependent Proteases Can Teach Us About the 26S Proteasome (pages 215–247)

      Nadia Benaroudj, David Smith and Alfred L. Goldberg

    12. Chapter 11

      Biochemical Functions of Ubiquitin and Ubiquitin-like Protein Conjugation (pages 249–278)

      Mark Hochstrasser

    13. You have free access to this content
      Index (pages 279–286)

  3. Part III: Cell Biology of the Ubiquitin–Proteasome System

    1. You have free access to this content
      Front Matter (pages I–XIV)

    2. Chapter 1

      Ubiquitin: A New Player in the Peroxisome Field (pages 1–20)

      Astrid Kragt, Rob Benne and Ben Distel

    3. Chapter 2

      The Ubiquitin Proteasome System and Muscle Development (pages 21–47)

      Johnny Kim and Thorsten Hoppe

    4. Chapter 3

      The COP9 Signalosome: Structural and Biochemical Conservation and Its Roles in the Regulation of Plant Development (pages 48–75)

      Vicente Rubio and Xing Wang Deng

    5. Chapter 4

      Ubiquitin and Protein Sorting to the Lysosome (pages 76–102)

      John McCullough, Michael J. Clague and Sylvie Urbé

    6. Chapter 5

      ISG15-dependent Regulation (pages 103–131)

      Arthur L. Haas

    7. Chapter 6

      The Role of the Ubiquitin–Proteasome Pathway in the Regulation of the Cellular Hypoxia Response (pages 132–148)

      Koh Nakayama and Ze'ev Ronai

    8. Chapter 7

      p97 and Ubiquitin: A Complex Story (pages 149–193)

      Louise C. Briggs, Ingrid Dreveny, Valerie E. Pye, Fabienne Beuron, Ciarán F. McKeown, Xiaodong Zhang and Paul S. Freemont

    9. Chapter 8

      Cdc48 (p97) and Its Cofactors (pages 194–211)

      Alexander Buchberger

    10. Chapter 9

      Deubiquitinating Enzymes, Cell Proliferation, and Cancer (pages 212–231)

      Rohan T. Baker

    11. You have free access to this content
      Index (pages 232–238)

  4. Part IV: The Ubiquitin–Proteasome System and Disease

    1. You have free access to this content
      Front Matter (pages I–XV)

    2. Chapter 1

      Ubiquitin Signaling and Cancer Pathogenesis (pages 1–20)

      Kaisa Haglund and Ivan Dikic

    3. Chapter 2

      Regulation of the p53 Tumor-Suppressor Protein by Ubiquitin and Ubiquitin-Like Molecules (pages 21–45)

      Dimitris P. Xirodimas

    4. Chapter 3

      The Ubiquitin–Proteasome System in Epstein-Barr Virus Infection and Oncogenesis (pages 47–75)

      Maria G. Masucci

    5. Chapter 4

      HECT Ubiquitin-Protein Ligases in Human Disease (pages 77–105)

      Martin Scheffner and Olivier Staub

    6. Chapter 5

      Ubiquitin-Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome (pages 107–121)

      Martin A. Hoyt and Philip Coffino

    7. Chapter 6

      Endoplasmic Reticulum Protein Quality Control and Degradation (pages 123–143)

      Antje Schäfer, Zlatka Kostova and Dieter H. Wolf

    8. Chapter 7

      Interactions between Viruses and the Ubiquitin–Proteasome System (pages 145–168)

      Jessica M. Boname and Paul J. Lehner

    9. Chapter 8

      The Ubiquitin–Proteasome System in Parkinson's Disease (pages 169–194)

      Kevin St. P. McNaught

    10. Chapter 9

      The Molecular Pathway to Neurodegeneration in Parkin-Related Parkinsonism (pages 195–210)

      Ryosuke Takahashi

    11. Chapter 10

      Parkin and Neurodegeneration (pages 211–236)

      Sathya R. Sriram, Valina L. Dawson and Ted M. Dawson

    12. You have free access to this content
      Index (pages 237–242)

SEARCH