Amyloid Proteins: The Beta Sheet Conformation and Disease

Amyloid Proteins: The Beta Sheet Conformation and Disease

Editor(s): Jean D. Sipe

Published Online: 23 JAN 2008

Print ISBN: 9783527310722

Online ISBN: 9783527619344

DOI: 10.1002/9783527619344

About this Book

A first-stop reference on proteins associated with amyloidosis.
This book is the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology. It considers the clinically recognized amyloid proteins that are known to be associated with the amyloid protein folding disorders, dealing with their common structural and thermodynamic features that lead to amyloid fibril formation and disease. Emphasis is on the thermodynamics of protein folding, the structure and physiologic effects of common oligomeric and subfibrillar intermediates and the influence of the extracellular matrix and cellular trafficking and metabolism on the genesis and catabolism of beta pleated sheet proteins.
The chapters on specific amyloid proteins all follow a common structure, allowing quick access to the desired biochemical and medical data, making this an invaluable tool for clinicians and researchers alike.

Table of contents

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  1. Part I: Overview of Amyloidosis and Amyloid Proteins

  2. Part II: Protein Structure and the Beta Pleated Sheet Conformation

  3. Part III: Protein Folding,Unfolding and Refolding

  4. Part IV: Pathway to Amyloid Fibril Formation

  5. Part V: Pathophysiology of Amyloid Fibril Formation

  6. Part VI: Amyloid Proteins

    1. Chapter 17

      The Amyloid β Protein (pages 384–491)

      Noel D. Lazo, Samir K. Maji, Erica A Fradinger, Gal Bitan and David B. Teplow

    2. Chapter 19

      Familial British and Danish Dementias (pages 515–526)

      Jorge Ghiso, Agueda Rostagno, Yasushi Tomidokoro, Tammaryn Lashley, Janice L. Holton, Gordon Plant, Tamas Revesz and Blas Frangione

    3. Chapter 21

      Transthyretin (pages 571–588)

      Ana Margarida Damas and Maria João Saraiva

    4. Chapter 23

      Gelsolin (pages 625–634)

      Hadar Benyamini, Kannan Gunasekaran, Haim Wolfson and Ruth Nussinov

    5. Chapter 24

      Lysozyme (pages 635–656)

      Mireille Dumoulin, Vittorio Bellotti and Christopher M. Dobson

    1. You have free access to this content
    1. You have free access to this content