Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3

Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3

Editor(s): Stuart L. Schreiber, Tarun M. Kapoor, Günther Wess

Published Online: 21 APR 2008

Print ISBN: 9783527311507

Online ISBN: 9783527619375

DOI: 10.1002/9783527619375

About this Book

Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology.
Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field.
No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work.

Table of contents

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  1. Part I: Chemistry and Biology — Historical and Philosophical Aspects - Introduction

  2. Part II: Using Small Molecules to Explore Biology - Using Natural Products to Unravel Biological Mechanisms

  3. Part II: Using Small Molecules to Explore Biology - Engineering Control Over Protein Function Using Chemistry

  4. Part II: Using Small Molecules to Explore Biology - Controlling Protein-Protein Interactions

  5. Part II: Using Small Molecules to Explore Biology - Expanding the Genetic Code

  6. Part III: Discovering Small Molecule Probes for Biological Mechanisms

  7. Part III: Discovering Small Molecule Probes for Biological Mechanisms - Reverse Chemical Genetics Revisited

  8. Part III: Discovering Small Molecule Probes for Biological Mechanisms - Tags and Probes for Chemical Biology

  9. Part IV: Expanding the Scope of Chemical Synthesis - Diversity-Oriented Synthesis

  10. Part IV: Expanding the Scope of Chemical Synthesis - Diversity-oriented Synthesis

  11. Part IV: Expanding the Scope of Chemical Synthesis - Synthesis of Large Biological Molecules

  12. Part IV: Expanding the Scope of Chemical Synthesis - Advances in Sugar Chemistry

  13. Part IV: Expanding the Scope of Chemical Synthesis

    1. Chapter 12

      The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors (pages 693–720)

      Paul A. Townsend, Simon J. Crabb, Sean M. Davidson, Peter W. M. Johnson, Graham Packham and Arasu Ganesan

  14. Part V: Chemical Informatics - Chemical Informatics

    1. Chapter 13

      WOMBAT and WOMBAT-PK: Bioactivity Databases for Lead and Drug Discovery (pages 760–786)

      Marius Olah, Ramona Rad, Liliana Ostopovici, Alina Bora, Nicoleta Hadaruga, Dan Hadaruga, Ramona Moldovan, Adriana Fulias, Maria Mractc and Tudor I. Oprea

  15. Part VI: Drug Discovery - Chemical Biology and Drug Discovery

    1. Chapter 14

      The Molecular Basis of Predicting Druggability (pages 804–823)

      Bissau Al-Lazikani, Anna Gaulton, Gaia Paolini, Jerry Lanfear, John Overington and Andrew Hopkins

  16. Part VI: Drug Discovery - Target Families

    1. Chapter 15

      Chemical Biology of Kinases Studied by NMR Spectroscopy (pages 852–890)

      Marco Betz, Martin Vogtherr, Ulrich Schieborr, Bettina Elshorst, Susanne Grimme, Barbara Pescatore, Thomas Langer, Krishna Saxena and Harald Schwalbe

    2. Chapter 15

      The GPCR — 7TM Receptor Target Family (pages 933–978)

      Edgar Jacoby, Rochdi Bouhelal, Marc Gerspacher and Klaus Seuwen

  17. Part VI: Drug Discovery

  18. Part VII: Systems Biology - Computational Methods and Modeling

  19. Part VII: Systems Biology - Genome and Proteome Studies

  20. Part VIII: Outlook

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