Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Editor(s): Klaus-Michael Debatin, Simone Fulda

Published Online: 26 MAY 2008

Print ISBN: 9783527312375

Online ISBN: 9783527619665

DOI: 10.1002/9783527619665

About this Book

Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists, and those working in the pharmaceutical and biotechnological industries.

Table of contents

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  1. Part I: Death Receptor

  2. Part II: Mitochondria

    1. Chapter 6

      Role of Mitochondrial Proteins in Apoptosis (pages 185–221)

      Xavier Saelens, Nele Festjens, Lieselotte Vande Walle and Peter Vandenabeele

  3. Part III: Effector Systems

  4. Part IV: Bcl-2 Family

    1. Chapter 13

      The BH3-only Proteins Puma and Noxa: Two Brothers in Arms (pages 379–402)

      Miriam Erlacher, Ewa M. Michalak, Andreas Strasser and Andreas Villunger

  5. Part V: IAPs

  6. Part VI: Survival Pathways

    1. Chapter 18

      Survival Regulation by Ras and Raf (pages 490–513)

      H. C. A. Drexler, A. Galmiche, M. Hekman, S. Albert and U. R. Rapp

  7. Part VII: Oncogenes/Tumor Suppressor Genes

    1. Chapter 20

      p73 Affects Cell Fate and Tumorigenesis (pages 536–550)

      Safaa Ramadan, Emre Sayan, Andrew Oberst, Anissa Chikh, Valentina Pietroni, Alessandro Rufini, Gerry Melino and Francesca Bernassola

    2. Chapter 21

      RB and Cancer (pages 551–567)

      B. Nelson Chau, Jacqueline Bergseid and Jean Y. J. Wang

  8. Part VIII: Modulators

  9. Part IX: Lysosomes and Nonapoptotic Pathways

    1. Chapter 23

      Lysosomes and Nonapoptotic Pathways (pages 599–622)

      Thomas Kirkegaard-Sørensen, Nicole Fehrenbacher, Mads Gyrd-Hansen and Marja Jüüttelü

  10. Part X: Phagocytosis/Clearance

  11. Part XI: Model Systems

  12. Part XII: Molecular Diagnosis

    1. Chapter 27

      Molecular Imaging in Cancer (pages 705–727)

      Mahaveer Swaroop Bhojani, Bharathi Laxman, Brian D. Ross and Alnawaz Rehemtulla

  13. Part XIII: Cellular Stress, DNA Damage and Repair

    1. Chapter 30

      Hypoxia in Cancer (pages 777–798)

      Ester M. Hammond, Ioanna Papandreou and Amato J. Giaccia

  14. Part XIV: Molecular Targets and Therapeutics

    1. Chapter 35

      Cancer Therapy by Reactivation of the p53 Apoptosis Pathway (pages 891–912)

      Helene Stridh, Vladimir J. N. Bykov, Galina Selivanova and Klas G. Wiman

    2. Chapter 39

      Ceramide Signaling in Apoptosis and Cancer Therapy (pages 997–1013)

      Silke Kullmann, Volker Teichgrüher, Claudia R. Bollinger and Erich Gulhins

    3. Chapter 43

      Tumor Angiogenesis (pages 1087–1106)

      Jurgen Becker, Jörg Wilting and Lothar L. Schweigerer

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