Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies

Editor(s): Stefan Dübel

Published Online: 1 FEB 2008

Print ISBN: 9783527314539

Online ISBN: 9783527619740

DOI: 10.1002/9783527619740

About this Book

In this most comprehensive reference source for the development, production and therapeutic application of antibodies, Volume I contains general chapters presenting established technologies and clinical applications. Volume II provides a look at emerging technologies, new therapeutic concepts, and clinical studies. The third volume features detailed and specific information about each currently approved type of antibody, including the clinical data.
A must-have resource for academic researchers, decision makers in industry and healthcare professionals in the clinic.

Table of contents

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  1. Part I: Selecting and Shaping the Antibody Molecule

    1. Chapter 4

      Selection Strategies III: Transgenic Mice (pages 69–93)

      Marianne Brüggemann, Jennifer A. Smith, Michael J. Osborn and Xiangang Zou

    2. Chapter 7

      Molecular Engineering II: Antibody Affinity (pages 145–169)

      Lorin Roskos, Scott Klakamp, Meina Liang, Rosalin Arends and Larry Green

    3. Chapter 8

      Molecular Engineering III: Fc Engineering (pages 171–196)

      Matthias Peipp, Thomas Beyer, Michael Dechant and Thomas Valerius

  2. Part II: The Way into the Clinic

    1. Chapter 9

      Production and Downstream Processing (pages 199–237)

      Klaus Bergemann, Christian Eckermann, Patrick Garidel, Stefanos Grammatikos, Alexander Jacobi, Hitto Kaufmann, Ralph Kempken and Sandra Pisch-Heberle

    2. Chapter 12

      Regulatory Considerations (pages 277–300)

      Marjorie A. Shapiro, Patrick G. Swann and Melanie Hartsough

  3. Part III: Beyond IgG - Modified Antibodies

  4. Part IV: Emerging Concepts

    1. Chapter 8

      Emerging Therapeutic Concepts I: ADEPT (pages 501–513)

      Surinder K. Sharma, Kerry A. Chester and Kenneth D. Bagshawe

    2. Chapter 9

      Emerging Therapeutic Concepts II: Nanotechnology (pages 515–532)

      Dimiter S. Dimitrov, Igor A. Sidorov, Yang Feng, Ponraj Prabakaran, Michaela A. E. Arndt, Jürgen Krauss and Susanna M. Rybak

  5. Part V: Ongoing Clinical Studies

  6. Part VI: Approved Therapeutics

    1. Chapter 1

      Adalimumab (Humira) (pages 696–732)

      Hartmut Kupper, Jochen Salfeld, Daniel Tracey and Joachim R. Kalden

    1. Chapter 3

      Bevacizumab (Avastin) (pages 779–812)

      Eduardo Díaz-Rubio, Edith A. Perez and Guiseppe Giaccone

    1. Chapter 6

      99mTc-Fanolesomab (NeutroSpec) (pages 851–867)

      Christopher J. Palestro, Josephine N. Rini and Charito Love

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