Biotechnology: Bioprocessing, Volume 3, Second Edition

Biotechnology: Bioprocessing, Volume 3, Second Edition

Editor(s): H.-J. Rehm, G. Reed

Published Online: 26 MAY 2008

Print ISBN: 9783527283132

Online ISBN: 9783527620845

DOI: 10.1002/9783527620845

About this Book

Bioprocessing: an exciting new engineering discipline. It combines the development and optimization of biotechnological processes with effective strategies to recover and purify the desired products. Safety as well as cost play an important role here.
This volume covers the immensely differentiated spectrum of techniques and operations of bioprocessing, presented by the most competent experts in the field. An overview of upstream and downstream processing is given, fermentation and cell culture processes and the design of microbial fermenters are presented. A closing group of chapters is dedicated to issues of process validation, measurement, and regulation.
Topics included are: Industrial Cell Cultures/ Pharmaceutical Proteins/ Bioreactors/ Media and Air Sterilization/ Oxygen Transfer/ Scale Implications/ Fermentation Data Analysis/ Cell and Debris Removal/ Protein Purification/ Electrokinetic Separations/ Final Recovery Steps/ Process Validation

Table of contents

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    1. Introduction (pages 1–3)

      Gregory Stephanopoulos and G. Stephanopoulos

  1. Part I: Nature and Issues of Bioprocessing

    1. Chapter 2

      Industrial Animal Cell Culture (pages 23–38)

      Brian D. Kelley, Tzyy-Wen Chiou, Morris Rosenberg and Daniel I. C. Wang

  2. Part II: Product Formation (Upstream Processing)

    1. Chapter 13

      Anaerobic Fermentations (pages 295–318)

      Larry E. Erickson, Daniel Y. C. Fung and Pravate Tuitemwong

    2. Chapter 15

      Fermentation Data Analysis for Diagnosis and Control (pages 355–400)

      Gregory Stephanopoulos, Konstantin Konstantinov, Urs Saner and Toshiomi Yoshida

  3. Part III: Product Recovery and Purification

  4. Part IV: Process Validation, Regulatory Issues Product Recovery and Purification

    1. Chapter 27

      Analytical Protein Chemistry (pages 717–737)

      Srikanth Sundaram, David M. Yarmush and Martin L. Yarmush

  5. Part IV: Process Validation, Regulatory Issues

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