Molecular System Bioenergetics: Energy for Life

Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA

Molecular System Bioenergetics: Energy for Life

Editor(s): Valdur Saks

Published Online: 22 NOV 2007

Print ISBN: 9783527317875

Online ISBN: 9783527621095

DOI: 10.1002/9783527621095

About this Book

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About The Product

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.

Table of contents

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      Front Matter (pages I–XXVIII)

    1. Introduction: From the Discovery of Biological Oxidation to Molecular System Bioenergetics (pages 1–8)

      Prof. Valdur Saks

  3. Part I: Molecular System Bioenergetics: Basic Principles, Organization, and Dynamics of Cellular Energetics

    1. Chapter 1

      Cellular Energy Metabolism and Integrated Oxidative Phosphorylation (pages 9–27)

      Xavier M. Leverve, Nellie Taleux, Roland Favier, Cécile Batandier, Dominique Detaille, Anne Devin, Eric Fontaine and Michel Rigoulet

    2. Chapter 2

      Organization and Regulation of Mitochondrial Oxidative Phosphorylation (pages 29–58)

      Michel Rigoulet, Arnaud Mourier and Anne Devin

    3. Chapter 3

      Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling (pages 59–109)

      Prof. Valdur Saks, Claire Monge, Tiia Anmann and Petras P. Dzeja

    4. Chapter 4

      On the Network Properties of Mitochondria (pages 111–135)

      Miguel A. Aon, Sonia Cortassa and Brian O'Rourke

    5. Chapter 5

      Structural Organization and Dynamics of Mitochondria in the Cells in Vivo (pages 137–162)

      Andrey V. Kuznetsov

  4. Part II: Energy Transfer Networks, Metabolic Feedback Regulation, and Modeling of Cellular Energetics

    1. Chapter 6

      Mitochondrial VDAC and Its Complexes (pages 163–194)

      Dieter Brdiczka

    2. Chapter 7

      The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation (pages 195–264)

      Theo Wallimann, Malgorzata Tokarska-Schlattner, Dietbert Neumann, Richard M. Epand, Raquel F. Epand, Robert H. Andres, Hans Rudolf Widmer, Thorsten Hornemann, Prof. Valdur Saks, Irina Agarkova and Uwe Schlattner

    3. Chapter 8

      Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics (pages 265–301)

      Petras P. Dzeja, Susan Chung and Andre Terzic

    4. Chapter 9

      Signaling by AMP-activated Protein Kinase (pages 303–338)

      Dietbert Neumann, Theo Wallimann, Mark H. Rider, Malgorzata Tokarska-Schlattner, D. Grahame Hardie and Uwe Schlattner

    5. Chapter 10

      Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase–Deficient Mice: Understanding CK's Role in the Fuelling of Behavior and Learning (pages 339–366)

      Femke Streijger, René in 't Zandt, Klaas Jan Renema, Frank Oerlemans, Arend Heerschap, Jan Kuiper, Helma Pluk, Caroline Jost, Ineke van der Zee and Bé Wieringa

    6. Chapter 11

      System Analysis of Cardiac Energetics–Excitation–Contraction Coupling: Integration of Mitochondrial Respiration, Phosphotransfer Pathways, Metabolic Pacing, and Substrate Supply in the Heart (pages 367–405)

      Prof. Valdur Saks, Petras P. Dzeja, Rita Guzun, Mayis K. Aliev, Marko Vendelin, André Terzic and Theo Wallimann

    7. Chapter 12

      Principles of Mathematical Modeling and in Silico Studies of Integrated Cellular Energetics (pages 407–433)

      Marko Vendelin, Prof. Valdur Saks and Jüri Engelbrecht

    8. Chapter 13

      Modeling Energetics of Ion Transport, Membrane Sensing and Systems Biology of the Heart (pages 435–455)

      Satoshi Matsuoka, Hikari Jo, Masanori Kuzumoto, Ayako Takeuchi, Ryuta Saito and Akinori Noma

  5. Part III: Applied Molecular System Bioenergetics

    1. Chapter 14

      Mitochondrial Adaptation to Exercise and Training: A Physiological Approach (pages 457–478)

      Kent Sahlin

    2. Chapter 15

      Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology (pages 479–520)

      Enn Seppet, Zemfira Gizatullina, Sonata Trumbeckaite, Stephan Zierz, Frank Striggow and Frank Norbert Gellerich

    3. Chapter 16

      Tumor Cell Energetic Metabolome (pages 521–540)

      Sybille Mazurek

    4. Chapter 17

      AMPK and the Metabolic Syndrome (pages 541–569)

      Benoit Viollet and Fabrizio Andreelli

    5. Chapter 18

      A Systems Biology Perspective on Obesity and Type 2 Diabetes (pages 571–592)

      Jolita Ciapaite, Stephan J. L. Bakker, Robert J. Heine, Klaas Krab and Hans V. Westerhoff

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      Subject Index (pages 593–604)

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      Related Titles (page 605)

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