Molecular Drug Properties - Measurement and Prediction

Molecular Drug Properties - Measurement and Prediction

Editor(s): Raimund Mannhold

Published Online: 4 MAR 2008

Print ISBN: 9783527317554

Online ISBN: 9783527621286

DOI: 10.1002/9783527621286

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.

Table of contents

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  1. Part I: Introduction

  2. Part II: Electronic Properties and H-Bonding

  3. Part III: Conformations

  4. Part IV: Solubility

  5. Part V: Lipophilicity

    1. Chapter 13

      Chromatographic Approaches for Measuring Log P (pages 331–355)

      Sophie Martel, Davy Guillarme, Yveline Henchoz, Alexandra Galland, Jean-Luc Veuthey, Serge Rudaz and Pierre-Alain Carrupt

  6. Part VI: Drug- and Lead-likeness

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