Antitargets: Prediction and Prevention of Drug Side Effects

Antitargets: Prediction and Prevention of Drug Side Effects

Editor(s): Roy J. Vaz, Thomas Klabunde

Published Online: 26 MAY 2008

Print ISBN: 9783527318216

Online ISBN: 9783527621460

DOI: 10.1002/9783527621460

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several highly instructive case studies that may be used as guidelines on how to improve drug development projects.
With its large section on ADME-related effects, this is key knowledge for every drug developer.

Table of contents

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  1. Part I: General Aspects

  2. Part II: Antitargets: Ion Channels and GPCRs

  3. Part III: Antitargets: Cytochrome P450s and Transporters

    1. Chapter 12

      MetaSite: Understanding CYP Antitarget Modeling for Early Toxicity Detection (pages 277–292)

      Yasmin Aristei, Gabriele Cruciani, Sergio Clementi, Emanuele Carosati, Riccardo Vianello and Paolo Benedetti

  4. Part IV: Case Studies of Drug Optimization Against Antitargets

    1. Chapter 18

      Strategy and Tactics for hERG Optimizations (pages 423–455)

      Craig Jamieson, Elizabeth M. Moir, Zoran Rankovic and Grant Wishart

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