Clinical Proteomics: From Diagnosis to Therapy

Clinical Proteomics: From Diagnosis to Therapy

Editor(s): Jennifer E. Van Eyk, Michael J. Dunn

Published Online: 8 APR 2008

Print ISBN: 9783527316373

Online ISBN: 9783527622153

DOI: 10.1002/9783527622153

About this Book

Unparalleled in its scope and depth, this book brings together proteomic approaches in diagnosis and treatment from all clinical fields, including clinical toxicology. The result is a new discipline in molecular medicine that will revolutionize the treatment and prevention of cancer, stroke and other severe diseases.
Following an overview of clinical proteomics, the authors look at the technologies available, before moving on to cancer, cardiopulmonary disease, diabetes and stroke. A whole section is devoted to toxicity and the work is rounded off with a discussion of the future of clinical proteomics.

Table of contents

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  1. Part I: Technologies

    1. Chapter 2

      Protein Separation by Two-Dimensional Electrophoresis (pages 13–29)

      Pamela M. Donoghue, Miroslava Stastna and Prof. Dr. Michael J. Dunn

    2. Chapter 5

      IEF Analysis of Peptides for Biomarkers Discovery (pages 61–71)

      Ali R. Vaezzadeh, Catherine G. Zimmermann-Ivol, Jacques Deshusses, Alexander Scherl and Denis F. Hochstrasser

    3. Chapter 6

      Capillary Electrophoretic Separations for Clinical Proteomics (pages 73–88)

      Brian M. Balgley, Weijie Wang, Xueping Fang, Don L. DeVoe and Cheng S. Lee

  2. Part II: Cancer

    1. Chapter 12

      Development and Use of Reversed-Phase Protein Microarrays for Clinical Applications (pages 165–175)

      Virginia Espina, Julia Wulfkuhle, Valerie S. Calvert, Kirsten H. Edmiston, Lance A. Liotta and Emanuel F. Petricoin

    2. Chapter 13

      Cyclin-Dependent Kinase Inhibitors and Cancer: Usefulness of Proteomic Approaches in Assessment of the Molecular Mechanisms and Efficacy of Novel Therapeutics (pages 177–202)

      Marian Hajduch, Helena Skalnikova, Petr Halada, David Vydra, Petr Dzubak, Marta Dziechciarkova, Miroslav Strnad, Danuta Radioch, Suresh Jivan Gadher and Hana Kovarova

  3. Part III: Cardiac Disease

    1. Chapter 14

      Diagnostic Markers for Monitoring Heart Transplant Rejection (pages 203–215)

      Dr. Ciara A. McManus, Professor Marlene L. Rose and Prof. Dr. Michael J. Dunn

  4. Part IV: Vascular Disease: Pulmonary, Diabetes and Brain

    1. Chapter 21

      Pulmonary Proteomics (pages 323–347)

      Jan Hirsch, Lorraine B. Ware and Michael A. Matthay

    2. Chapter 22

      Proteomics Providing Insights into Major Psychiatric Disorders (pages 349–377)

      Melanie Föcking, Kyla Pennington, Jane English, Prof. Dr. Michael Dunn and David Cotter

  5. Part V: Toxicity, Bacterial and Viral Infections

  6. Part VI: Autoimmune Disease and Autoantibodies

    1. Chapter 27

      Application of Fungal Cyclic Peptides and Metabolites (pages 481–509)

      Jan Nedvěd, Miroslav Sulc, Alexandr Jegorov, Anastassios Giannakopulos and Vladimir Havlicek

    2. Chapter 30

      Antibody and Reverse Capture Protein Microarrays for Clinical Proteomics (pages 549–569)

      Harvey B. Pollard, Ofer Eidelman, Meera Srivastava, Catherine Joswik, Stephen Rothwell, Gregory P. Mueller, David M. Jacobowitz, William B. Guggino, Jerry Wright, Pamela L. Zeitlin and Cloud P. Paweletz

    3. Chapter 31

      Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases (pages 571–592)

      Rodney Lui, Angus Brown, Bosco Wu, Ming-Wei Lin, John Thompson, Filip Braet, Wayne Dyer, JoDee Lattimore, Peter Macdonald, Stephen Adelstein and Cristobal G. dos Remedios

  7. Part VII: Translation: Discovery to the Clinic

    1. Chapter 34

      Translation of Protein Biomarkers for Clinical Development (pages 633–651)

      Ian McCaffery, V. Dan Fitzpatrick, Shen Wu Wang, John M. Rossi, Haifeng Bao, Sid V. Suggs, John Ferbas and Scott D. Patterson

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